ArticleBMC veterinary research2018
Virulence gene profiles: alpha-hemolysin and clonal diversity in Staphylococcus aureus isolates from bovine clinical mastitis in China.
Article in BMC veterinary research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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30 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- The prevalence of adhesion and biofilm genes in Staphylococcus aureus isolates from bovine mastitis: A comprehensive meta-analysis.Veterinary medicine and science · 2024Pooled it
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- Antimicrobial resistance and molecular characteristics of bovine mastitis-associated methicillin-resistantMicrobiology spectrum · 2025Article
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- Ferroptosis-Related Genes as Molecular Markers in Bovine Mammary Epithelial Cells Challenged withInternational journal of molecular sciences · 2025Article
- Virulence of Bacteria Causing Mastitis in Dairy Cows: A Literature Review.Microorganisms · 2025Review
- Characteristic profiles of molecular types, antibiotic resistance, antibiotic resistance genes, and virulence genes ofFrontiers in cellular and infection microbiology · 2025Article
- Zoonotic transmission of asymptomatic carriageMicrobial genomics · 2024Article
- An Investigation of Virulence Genes ofAnimals : an open access journal from MDPI · 2024Article
- Exploring the modulatory impact of isosakuranetin onVirulence · 2023Article
- Occurrence of Virulence Genes among Methicillin-ResistantACS omega · 2023Article
- Advances in Diagnostic Approaches and Therapeutic Management in Bovine Mastitis.Veterinary sciences · 2023Review
- Genomic and phenotypic profiling of Staphylococcus aureus isolates from bovine mastitis for antibiotic resistance and intestinal infectivity.BMC microbiology · 2023Article
- Antimicrobial resistance and virulence profiles of staphylococci isolated from clinical bovine mastitis.Frontiers in microbiology · 2023Article
- Prevalence, Infectious Characteristics and Genetic Diversity ofPathogens (Basel, Switzerland) · 2022Article
- Antibiotic Resistance and Molecular Profiling of the Clinical Isolates ofMicroorganisms · 2022Article
- Diversity and pathogenesis of Staphylococcus aureus from bovine mastitis: current understanding and future perspectives.BMC veterinary research · 2022Review
- Inhibitory Effect ofFrontiers in pharmacology · 2022Article
- The Role of microRNAs in the Mammary Gland Development, Health, and Function of Cattle, Goats, and Sheep.Non-coding RNA · 2021Review
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundStaphylococcus aureus, a common cause of bovine mastitis, is known for its ability to acquire to antimicrobial resistance and to secrete numerous virulence factors that can exacerbate inflammation. In addition, alpha-hemolysin has an important role in S. aureus infections, diversity of the hla gene (that produces alpha-hmolysin) in S. aureus isolated from bovine mastitis has not been well characterized. The objective was, therefore, to determine diversity of virulence genes, hla gene sequences, and clonal profiles of S. aureus from bovine mastitis in Chinese dairy herds, and to evaluate inter-relationships.
resultsThe antimicrobials resistance varies from as low as 1.9% (2/103) for CTX to as high as 76.7% (79/103) for penicilin in the 103 isolates and 46 (44.7%) S. aureus were determined as multi-resistant isolates with diverse resistance patterns. Thirty-eight virulence gene patterns (with variable frequencies) were identified in the 103 isolates and correlated with MLST types, indicating a great diversity. Although the hla gene also had great diversity (14 genotypes), Hla peptides were relatively more conserved. With 7 clonal complexes identified from 24 spa types and 7 MLST types. Regarding the letter, ST 97 was the dominant type in S. aureus from bovine mastitis in China. Furthermore, based on phylogenetic analysis, there was a distinct evolutionary relationship between the hla gene and MLST.
conclusionMulti-resistant S. aureus occurred in bovine mastitis with diverse resistance patterns. The diversity of virulence gene profiles, especially the hla gene and, their relationship with molecular types were reported for the first time in S. aureus from bovine mastitis, which will be useful for future studies on immunogenicity and vaccine development. In addition, based on the distinct evolutionary relationship between the hla gene and MLST types, we inferred that the hla gene has potential role for molecular typing of S. aureus.
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