ArticleInternational journal for parasitology. Drugs and drug resistance2018
17-DMAG inhibits the multiplication of several Babesia species and Theileria equi on in vitro cultures, and Babesia microti in mice.
Article in International journal for parasitology. Drugs and drug resistance, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Targeting piroplasmosis and theileriosis: New frontiers in drug development.Tropical animal health and production · 2025Pooled it
- Human babesiosis: The past, present and future.Expert reviews in molecular medicine · 2025Review
- Article
- Intraperitoneal Administration of 17-DMAG as an Effective Treatment againstPathogens (Basel, Switzerland) · 2024Article
- Alvespimycin Exhibits Potential Anti-TGF-β Signaling in the Setting of a Proteasome Activator in Rats with Bleomycin-Induced Pulmonary Fibrosis: A Promising Novel Approach.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Review
- Tafenoquine Is a Promising Drug Candidate for the Treatment of Babesiosis.Antimicrobial agents and chemotherapy · 2021Article
- Anti-International journal of molecular sciences · 2021Article
- Development and Characterization of PLGA Nanoparticles Containing 17-DMAG, an Hsp90 Inhibitor.Frontiers in chemistry · 2021Article
- Twenty Years of Equine Piroplasmosis Research: Global Distribution, Molecular Diagnosis, and Phylogeny.Pathogens (Basel, Switzerland) · 2020Review
- Myrrh OilPathogens (Basel, Switzerland) · 2020Article
- Therapeutic Effects of Atranorin towards the Proliferation ofPathogens (Basel, Switzerland) · 2020Article
- Phytochemical Screening and Antiprotozoal Effects of the MethanolicMolecules (Basel, Switzerland) · 2020Article
- Safety and efficacy of hydroxyurea and eflornithine against most blood parasites Babesia and Theileria.PloS one · 2020Article
- Screening the Medicines for Malaria Venture Pathogen Box against piroplasm parasites.International journal for parasitology. Drugs and drug resistance · 2019Article
- Ellagic acid microspheres restrict the growth of Babesia and Theileria in vitro and Babesia microti in vivo.Parasites & vectors · 2019Article
- The effects of trans-chalcone and chalcone 4 hydrate on the growth of Babesia and Theileria.PLoS neglected tropical diseases · 2019Article
- Unravelling the cellular and molecular pathogenesis of bovine babesiosis: is the sky the limit?International journal for parasitology · 2019Review
- Evaluation of the inhibitory effect of ivermectin on the growth ofTropical medicine and health · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat shock protein 90 (Hsp90) is a chaperone protein that stabilizes cells during stress or non-stress responses. Previous reports have shown that Hsp90 is a potential drug target to suppress the multiplication of several protozoan parasites. In this study, 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), an Hsp90 inhibitor, was evaluated for its inhibitory effect on five in vitro cultures of Babesia and Theileria species, including B. bovis, B. bigemina, B. divergens, B. caballi, and T. equi, and on the multiplication of a B. microti-infected mouse model. 17-DMAG showed the inhibitory effect in all of the species tested. The half maximum inhibition concentration (IC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.