Evidence map›Paper›PMID 29499563›Full record

ArticleRedox biology2018

Astrocytic CCAAT/Enhancer-binding protein delta contributes to reactive oxygen species formation in neuroinflammation.

Shao-Ming Wang, Sher-Wei Lim, Ya-Han Wang, Hong-Yi Lin, Ming-Derg Lai, Chiung-Yuan Ko, Ju-Ming Wang

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Shao-Ming WangInstitute of Basic Medical Sciences, College of Medicine, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan; Center for Neurotrauma and Neuroregeneration, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan; The Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan.
Sher-Wei LimInstitute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Departments of Neurosurgery, Chi-Mei Medical Center, Tainan 722, Taiwan; Department of Nursing, Min-Hwei College of Health Care Management, Tainan 736, Taiwan.
Ya-Han WangDepartment of Life Science, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan.
Hong-Yi LinThe Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan.
Ming-Derg LaiInstitute of Basic Medical Sciences, College of Medicine, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan.
Chiung-Yuan KoCenter for Neurotrauma and Neuroregeneration, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan; The Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan. Electronic address: ko680108@tmu.edu.tw.
Ju-Ming WangInstitute of Basic Medical Sciences, College of Medicine, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan; Graduate Institute of Medical Sciences, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: yumingw@mail.ncku.edu.tw.
Taipei Medical University · TWNational Cheng Kung University · TWChi Mei Medical Center · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive reactive oxygen species (ROS) can form an oxidative stress and an associated neuroinflammation. However, the contribution of astrocytes to ROS formation, the cause of the resistance of astrocytes to oxidative stress, and the consequences on neurons remain largely uninvestigated. The transcription factor CCAAT/enhancer-binding protein delta (CEBPD) is highly expressed in astrocytes and has been suggested to contribute to the progress of Alzheimer's disease (AD). In this study, we found that ROS formation and expression of p47

Indexed as

Alzheimer DiseaseAnimalsApoptosisAstrocytesCCAAT-Enhancer-Binding Protein-deltaGene Expression RegulationHumansMiceNADPH OxidasesNeuronsOxidative StressPhosphoproteinsReactive Oxygen SpeciesSuperoxide DismutaseUp-RegulationCCAAT-Enhancer-Binding Protein-deltaNADPH Oxidasesneutrophil cytosol factor 67Kneutrophil cytosolic factor 1PhosphoproteinsReactive Oxygen SpeciesSuperoxide DismutaseAstrocyteCEBPDROSSOD1 and neuroinflammation

Identifiers

PMID29499563
PMCPMC5953220
OpenAlexW2802314963

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.