Evidence map›Paper›PMID 29499416›Full record

ReviewBone2018

Amino acids as signaling molecules modulating bone turnover.

Ke-Hong Ding, Michael Cain, Michael Davis, Clare Bergson, Meghan McGee-Lawrence, Crystal Perkins, Trevor Hardigan, Xingming Shi, Qing Zhong, Jianrui Xu and 8 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bone, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Metabolomic biomarkers of low BMD: a systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Pooled it
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  17. A 1:1 matched case-control study on dietary protein intakes and hip fracture risk in Chinese elderly men and women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Ke-Hong DingInstitute for Regenerative and Reparative Medicine, Medical College of Georgia, Augusta University, USA; Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, USA.
Michael CainDepartment of Orthopaedic Surgery, Medical College of Georgia, Augusta University, USA.
Michael DavisInstitute for Regenerative and Reparative Medicine, Medical College of Georgia, Augusta University, USA.
Clare BergsonDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, USA.
Meghan McGee-LawrenceInstitute for Regenerative and Reparative Medicine, Medical College of Georgia, Augusta University, USA; Department of Orthopaedic Surgery, Medical College of Georgia, Augusta University, USA; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, USA.
Crystal PerkinsInstitute for Regenerative and Reparative Medicine, Medical College of Georgia, Augusta University, USA.
Trevor HardiganInstitute for Regenerative and Reparative Medicine, Medical College of Georgia, Augusta University, USA.
Xingming ShiInstitute for Regenerative and Reparative Medicine, Medical College of Georgia, Augusta University, USA; Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, USA.
Qing ZhongInstitute for Regenerative and Reparative Medicine, Medical College of Georgia, Augusta University, USA; Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, USA.
Jianrui XuInstitute for Regenerative and Reparative Medicine, Medical College of Georgia, Augusta University, USA; Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, USA.
Wendy B BollagInstitute for Regenerative and Reparative Medicine, Medical College of Georgia, Augusta University, USA; Department of Medicine, Medical College of Georgia, Augusta University, USA; Department of Physiology, Medical College of Georgia, Augusta University, USA; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, USA; Charlie Norwood VA Medical Center, School of Dental Medicine, Augusta, GA 30912, USA.
William HillInstitute for Regenerative and Reparative Medicine, Medical College of Georgia, Augusta University, USA; Department of Orthopaedic Surgery, Medical College of Georgia, Augusta University, USA; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, USA; Charlie Norwood VA Medical Center, School of Dental Medicine, Augusta, GA 30912, USA.
Mohammed ElsalantyDepartment of Oral Biology, School of Dental Medicine, Augusta, GA 30912, USA.
Monte HunterInstitute for Regenerative and Reparative Medicine, Medical College of Georgia, Augusta University, USA; Department of Orthopaedic Surgery, Medical College of Georgia, Augusta University, USA.
Maria C IsalesInstitute for Regenerative and Reparative Medicine, Medical College of Georgia, Augusta University, USA.
Patricia LopezInstitute for Regenerative and Reparative Medicine, Medical College of Georgia, Augusta University, USA.
Mark HamrickInstitute for Regenerative and Reparative Medicine, Medical College of Georgia, Augusta University, USA; Department of Orthopaedic Surgery, Medical College of Georgia, Augusta University, USA; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, USA.
Carlos M IsalesInstitute for Regenerative and Reparative Medicine, Medical College of Georgia, Augusta University, USA; Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, USA; Department of Orthopaedic Surgery, Medical College of Georgia, Augusta University, USA; Department of Medicine, Medical College of Georgia, Augusta University, USA; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, USA. Electronic address: cisales@augusta.edu.
Augusta University · US

Funding

THE LEPTIN-IGF1 AXIS IN MUSCULOSKELETAL AGINGP01AG036675 · NIA · AUGUSTA UNIVERSITY · PI Mark W Hamrick · 2011 to 2026
$31.5M
Bad to the Bone: Age-related Increases in Serum SDF-1 Leads to Bone Loss with AgeI01CX000930 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI HILL, WILLIAM D · 2014 to 2019
–
CSRD VA I01 CX000930NIA NIH HHS P01 AG036675
6 · The paper itself

Abstract

Except for the essential amino acids (AAs), much of the focus on adequate dietary protein intake has been on total nitrogen and caloric intake rather than AA composition. Recent data, however, demonstrate that "amino-acid sensing" can occur through either intracellular or extracellular nutrient-sensing mechanisms. In particular, members of the class 3 G-protein coupled receptor family, like the calcium-sensing receptor are known to preferentially bind specific AAs, which then modulate receptor activation by calcium ions and thus potentially impact bone turnover. In pursuing the possibility of direct nutrient effects on bone cells, we examined individual AA effects on osteoprogenitor/bone marrow stromal cells (BMSCs), a key target for bone anabolism. We demonstrate that BMSCs express both intracellular and extracellular nutrient sensing pathways and that AAs are required for BMSC survival. In addition, certain AA types, like members of the aromatic AAs, can potently stimulate increases in intracellular calcium and ERK phosphorylation/activation. Further, based on the in vitro data, we examined the effect of specific AAs on bone mass. To better evaluate the impact of specific AAs, we added these to a low-protein diet. Our data demonstrate that a low-protein diet itself is associated with a significant drop in bone mineral density (BMD) in the older mice, related, at least in part, to an increase in osteoclastic activity. This drop in BMD in mice on the low-protein diet is prevented by addition of AAs from the aromatic group. Taken together our data show that AAs function as specific and selective signaling molecules in bone cells.

Indexed as

Amino AcidsAnimalsBone RemodelingDietHumansSignal TransductionAmino AcidsAmino acidsNutrientsSignalingStem cells

Identifiers

PMID29499416
PMCPMC6110952
OpenAlexW2790984330

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.