Evidence map›Paper›PMID 29499295›Full record

ArticleJournal of the American Academy of Dermatology2018

Similar survival of patients with multiple versus single primary melanomas based on Utah Surveillance, Epidemiology, and End Results data (1973-2011).

Douglas Grossman, James M Farnham, John Hyngstrom, Marki E Klapperich, Aaron M Secrest, Sarah Empey, Glen M Bowen, David Wada, Robert H I Andtbacka, Kenneth Grossmann and 2 more

Abstract read
In one paragraph

Article in Journal of the American Academy of Dermatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Survival impact of second primary cutaneous and non-cutaneous melanoma in melanoma survivors.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Douglas GrossmanDepartment of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah; Department of Oncological Sciences, University of Utah Health Sciences Center, Salt Lake City, Utah; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah. Electronic address: doug.grossman@hci.utah.edu.
James M FarnhamDepartment of Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah.
John HyngstromDepartment of Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah.
Marki E KlapperichUniversity of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Aaron M SecrestDepartment of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah.
Sarah EmpeyHuntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah.
Glen M BowenDepartment of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah.
David WadaDepartment of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah.
Robert H I AndtbackaDepartment of Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah.
Kenneth GrossmannDepartment of Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah.
Tawnya L BowlesDepartment of Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah.
Lisa A Cannon-AlbrightDepartment of Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah; George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah.
Huntsman Cancer Institute · USUniversity of Utah · USGeorge E. Wahlen Department of VA Medical Center · USUniversity of Wisconsin–Madison · US

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
High-throughput sequencing to identify novel melanoma susceptibility genesR01CA195614 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ALBRIGHT, LISA CANNON, HUFF, CHAD DANIEL · 2015 to 2019
$5.4M
NCI NIH HHS HHSN261201000026CNCI NIH HHS P30 CA042014NCI NIH HHS R01 CA195614
6 · The paper itself

Abstract

backgroundSurvival data are mixed comparing patients with multiple primary melanomas (MPM) to those with single primary melanomas (SPM).

objectivesWe compared MPM versus SPM patient survival using a matching method that avoids potential biases associated with other analytic approaches.

methodsRecords of 14,138 individuals obtained from the Surveillance, Epidemiology, and End Results registry of all melanomas diagnosed or treated in Utah between 1973 and 2011 were reviewed. A single matched control patient was selected randomly from the SPM cohort for each MPM patient, with the restriction that they survived at least as long as the interval between the first and second diagnoses for the matched MPM patient.

resultsSurvival curves (n = 887 for both MPM and SPM groups) without covariates showed a significant survival disadvantage for MPM patients (chi-squared 39.29, P < .001). However, a multivariate Cox proportional hazards model showed no significant survival difference (hazard ratio 1.07, P = .55). Restricting the multivariate analysis to invasive melanomas also showed no significant survival difference (hazard ratio 0.99, P = .96). LIMITATIONS: Breslow depth, ulceration status, and specific cause of death were not available for all patients.

conclusionsPatients with MPM had similar survival times as patients with SPM.

Indexed as

AdultAgedCause of DeathCutaneous Malignant MelanomaFemaleHumansKaplan-Meier EstimateMaleMatched-Pair AnalysisMelanomaMiddle AgedNeoplasms, Multiple PrimaryProportional Hazards ModelsSEER ProgramSkin NeoplasmsSkin Ulcermelanomamultiple primarySEERsurvival

Identifiers

PMID29499295
PMCPMC6754624
OpenAlexW2788416683

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.