Evidence map›Paper›PMID 29498804›Full record

ArticleThe FEBS journal2018

STRENDA DB: enabling the validation and sharing of enzyme kinetics data.

Neil Swainston, Antonio Baici, Barbara M Bakker, Athel Cornish-Bowden, Paul F Fitzpatrick, Peter Halling, Thomas S Leyh, Claire O'Donovan, Frank M Raushel, Udo Reschel and 9 more

Abstract read
In one paragraph

Article in The FEBS journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Review
  3. Advances in Machine Learning Models for Predicting Enzyme Kinetic Parameters.Journal of chemical information and modeling · 2026
    Review
  4. Primer on Modelling Approaches for Omics Data.Advances in experimental medicine and biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Enzyme Databases in the Era of Omics and Artificial Intelligence.International journal of molecular sciences · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. IntEnzyDB: an Integrated Structure-Kinetics Enzymology Database.Journal of chemical information and modeling · 2022
    Article
  19. Article
  20. Parameter Reliability and Understanding Enzyme Function.Molecules (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Neil SwainstonManchester Centre for Synthetic Biology of Fine and Speciality Chemicals, Manchester Institute of Biotechnology, University of Manchester, UK.
Antonio BaiciDepartment of Biochemistry, University of Zürich, Switzerland.
Barbara M BakkerUniversity Medical Center Groningen, University of Groningen, The Netherlands.
Athel Cornish-BowdenCNRS-IMM-BIP, Aix Marseille Univ, France.
Paul F FitzpatrickThe University of Texas Health Science Center, San Antonio, TX, USA.
Peter HallingWestCHEM, Department of Pure & Applied Chemistry, University of Strathclyde, Glasgow, UK.
Thomas S LeyhThe Albert-Einstein-College of Medicine, Bronx, NY, USA.
Claire O'DonovanEuropean Bioinformatics Institute, EMBL Outstation, Cambridge, UK.
Frank M RaushelDepartment of Chemistry, Texas A&M University, College Station, TX, USA.
Udo ReschelBeilstein-Institut, Frankfurt am Main, Germany.
Johann M RohwerDepartment of Biochemistry, University of Stellenbosch, South Africa.
Santiago SchnellDepartment of Molecular & Integrative Physiology, Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA.
Dietmar SchomburgBioinformatics and Systems Biology, Technical University of Braunschweig, Germany.
Keith F TiptonSchool of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.
Ming-Daw TsaiInstitute of Biochemical Sciences, Academia Sinica, Taipei, Taiwan.
Hans V WesterhoffManchester Centre for Integrative Systems Biology, School for Chemical Engineering and Analytical Science, University of Manchester, UK.
Ulrike WittigHeidelberg Institute for Theoretical Studies (HITS gGmbH), Germany.
Roland WohlgemuthMember of Merck Group, Sigma-Aldrich, Buchs, Switzerland.
Carsten KettnerBeilstein-Institut, Frankfurt am Main, Germany.ORCID 0000-0002-8697-6842

Funding

Interfacing computation and engineering with digestive and metabolic physiologyR25DK088752 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MACDOUGALD, ORMOND A · 2010 to 2020
$1.1M
Allosteric Regulation of Human Cytosolic SulfotransferasesR01GM121849 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI LEYH, THOMAS S. · 2017 to 2018
$888k
Biotechnology and Biological Sciences Research Council BB/K019783/1Biotechnology and Biological Sciences Research Council BB/M006891/1Biotechnology and Biological Sciences Research Council BB/M017702/1NIDDK NIH HHS R25 DK088752NIGMS NIH HHS R01 GM121849
6 · The paper itself

Abstract

Standards for reporting enzymology data (STRENDA) DB is a validation and storage system for enzyme function data that incorporates the STRENDA Guidelines. It provides authors who are preparing a manuscript with a user-friendly, web-based service that checks automatically enzymology data sets entered in the submission form that they are complete and valid before they are submitted as part of a publication to a journal.

Indexed as

User-Computer InterfaceAnimalsBacteriaDatabases, ProteinEnzyme AssaysEnzymesFungiGuidelines as TopicHumansInformation DisseminationKineticsPeriodicals as TopicPlantsValidation Studies as TopicEnzymes

Identifiers

PMID29498804
PMCPMC6005732

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.