Evidence map›Paper›PMID 29498797›Full record

ReviewAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2018

Visceral transplantation in patients with intestinal-failure associated liver disease: Evolving indications, graft selection, and outcomes.

Jason S Hawksworth, Chirag S Desai, Khalid M Khan, Stuart S Kaufman, Nada Yazigi, Raffaele Girlanda, Alexander Kroemer, Thomas M Fishbein, Cal S Matsumoto

Abstract readReview
In one paragraph

Review in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. New insights into intestinal failure-associated liver disease in adults: A comprehensive review of the literature.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jason S HawksworthMedStar Georgetown University Hospital, MedStar Georgetown Transplant Institute, Washington, DC, USA.
Chirag S DesaiDepartment of Surgery, Division of Abdominal Transplant, University of North Carolina, Chapel Hill, NC, USA.
Khalid M KhanMedStar Georgetown University Hospital, MedStar Georgetown Transplant Institute, Washington, DC, USA.
Stuart S KaufmanMedStar Georgetown University Hospital, MedStar Georgetown Transplant Institute, Washington, DC, USA.
Nada YazigiMedStar Georgetown University Hospital, MedStar Georgetown Transplant Institute, Washington, DC, USA.
Raffaele GirlandaMedStar Georgetown University Hospital, MedStar Georgetown Transplant Institute, Washington, DC, USA.
Alexander KroemerMedStar Georgetown University Hospital, MedStar Georgetown Transplant Institute, Washington, DC, USA.
Thomas M FishbeinMedStar Georgetown University Hospital, MedStar Georgetown Transplant Institute, Washington, DC, USA.
Cal S MatsumotoMedStar Georgetown University Hospital, MedStar Georgetown Transplant Institute, Washington, DC, USA.

Funding

UPIT: Unleash the Potential of Intestinal TransplantationR01AI132389 · NIAID · GEORGETOWN UNIVERSITY · PI KROEMER, ALEXANDER HELMUT KURT · 2017 to 2021
$2.4M
NIAID NIH HHS R01 AI132389
6 · The paper itself

Abstract

Intestinal failure (IF)-associated liver disease (IFALD) is widely recognized as a lethal complication of long-term parenteral nutrition. The pathophysiology of IFALD is poorly understood but appears to be multifactorial and related to the inflammatory state in the patient with IF. Visceral transplant for IFALD includes variants of intestine, liver, or combined liver-intestine allografts. Graft selection for an individual patient depends on the etiology of IF, abdominal and vascular anatomy, severity of IFALD, and potential for intestinal rehabilitation. The past decade has witnessed dramatic improvement in the management of IFALD, principally due to improved lipid emulsion formulations and the multidisciplinary care of the patient with IF. As the recognition and treatment of IFALD continue to improve, the requirement of liver-inclusive visceral grafts appears to be decreasing, representing a paradigm shift in the care of the patient with IF. This review highlights the current indications, graft selection, and outcomes of visceral transplantation for IFALD.

Indexed as

HumansIntestinal DiseasesLiver DiseasesParenteral NutritionVisceraclinical research/practiceintestinal (allograft) function/dysfunctionintestinal diseaseintestinal failure/injuryintestine/multivisceral transplantationliver (native) function/dysfunctionnutrition

Identifiers

PMID29498797
PMCPMC5992069

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.