ReviewNutrients2018
Regulation of Muscle Glycogen Metabolism during Exercise: Implications for Endurance Performance and Training Adaptations.
Review in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
115 citing papers in PubMed, 3 syntheses or guidelines pooled it, 235 citations in OpenAlex.
- Dietary Carbohydrate Intake and Skeletal Muscle Glycogen: A Systematic Review and Meta-Analysis to Determine Optimal Carbohydrate Loading Strategies.Scandinavian journal of medicine & science in sports · 2026Pooled it
- Acute effects of resistance exercise on skeletal muscle glycogen depletion: A systematic review and meta-analysis.Physiological reports · 2025Pooled it
- The Effects of Concurrent Training Combined with Low-Carbohydrate High-Fat Ketogenic Diet on Body Composition and Aerobic Performance: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Exogenous carbohydrate form during low-muscle glycogen conditions has minimal impact on cycling performance.Journal of the International Society of Sports Nutrition · 2026Trial
- Isolating the effects of carbohydrate and lipid availability on exercise-induced skeletal muscle signalling in males.The Journal of physiology · 2026Trial
- Comparative effects of continuous glucose monitoring-informed and traditional interval-based carbohydrate refueling protocols on endurance exercise responses: an exploratory study.Journal of the International Society of Sports Nutrition · 2025Trial
- Acute effects of intra-training carbohydrate ingestion in CrossFit® trained adults: a randomized, triple-blind, placebo-controlled crossover trial.European journal of applied physiology · 2025Trial
- Gut Microbial Stability is Associated with Greater Endurance Performance in Athletes Undertaking Dietary Periodization.mSystems · 2022Trial
- Effects of Trehalose Solutions at Different Concentrations on High-Intensity Intermittent Exercise Performance.Nutrients · 2022Trial
- Carbohydrate restriction following strenuous glycogen-depleting exercise does not potentiate the acute molecular response associated with mitochondrial biogenesis in human skeletal muscle.European journal of applied physiology · 2021Trial
- Is a Four-Week Ketogenic Diet an Effective Nutritional Strategy in CrossFit-Trained Female and Male Athletes?Nutrients · 2021Trial
- The causal pathway effects of a physical activity intervention on adiposity in children: The KISS Study cluster randomized clinical trial.Scandinavian journal of medicine & science in sports · 2020Trial
- Trial
- The Effect of Different Cadence on Paddling Gross Efficiency and Economy in Stand-Up Paddle Boarding.International journal of environmental research and public health · 2020Trial
- Acute Maltodextrin Supplementation During Resistance Exercise.Journal of sports science & medicine · 2020Trial
- Effects of 120 g/h of Carbohydrates Intake during a Mountain Marathon on Exercise-Induced Muscle Damage in Elite Runners.Nutrients · 2020Trial
- Low pre-exercise muscle glycogen availability offsets the effect of post-exercise cold water immersion in augmenting PGC-1α gene expression.Physiological reports · 2019Trial
- A targeted metabolic intervention via exercise applied after vaccination shapes kinetics and durability of serum antibody accompanied by a distinct immunometabolic signature: pilot study.Brain, behavior, & immunity - health · 2026Article
- The Effects of Different Dietary and Glycogen-Loaded Two-a-Day Training Approaches on Muscle Damage and Inflammatory Markers for Enhancing Metabolic Efficiency.Metabolites · 2026Article
- Preservation of Antioxidant and Immunomodulatory Properties in a Heat-Treated Probiotic Blend: Insights from Preclinical Models.Microorganisms · 2026Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the introduction of the muscle biopsy technique in the late 1960s, our understanding of the regulation of muscle glycogen storage and metabolism has advanced considerably. Muscle glycogenolysis and rates of carbohydrate (CHO) oxidation are affected by factors such as exercise intensity, duration, training status and substrate availability. Such changes to the global exercise stimulus exert regulatory effects on key enzymes and transport proteins via both hormonal control and local allosteric regulation. Given the well-documented effects of high CHO availability on promoting exercise performance, elite endurance athletes are typically advised to ensure high CHO availability before, during and after high-intensity training sessions or competition. Nonetheless, in recognition that the glycogen granule is more than a simple fuel store, it is now also accepted that glycogen is a potent regulator of the molecular cell signaling pathways that regulate the oxidative phenotype. Accordingly, the concept of deliberately training with low CHO availability has now gained increased popularity amongst athletic circles. In this review, we present an overview of the regulatory control of CHO metabolism during exercise (with a specific emphasis on muscle glycogen utilization) in order to discuss the effects of both high and low CHO availability on modulating exercise performance and training adaptations, respectively.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.