ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019
Quantitative blood flow measurement in rat brain with multiphase arterial spin labelling magnetic resonance imaging.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 42 citations in OpenAlex.
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- Bidirectional crusher gradient method to estimate the labeling efficiency of pseudo-continuous arterial spin labeling MRI in mice.Magnetic resonance in medicine · 2026Article
- Black-blood MRI at 7T using 2D RARE MRI: In vitro testing and in vivo demonstration.Zeitschrift fur medizinische Physik · 2026Article
- Three-dimensional high-resolution TMagnetic resonance in medicine · 2025Article
- High-resolution perfusion imaging in rodents using pCASL at 9.4 T.NMR in biomedicine · 2025Article
- Investigating the origin of theNMR in biomedicine · 2024Article
- In Vivo Visualization and Quantification of Rat Laryngeal Blood Supply After Hydration Challenge.The Laryngoscope · 2024Article
- Investigation of relayed nuclear Overhauser enhancement effect at -1.6 ppm in an ischemic stroke model.Quantitative imaging in medicine and surgery · 2023Article
- Comparison and optimization of pCASL and VSASL for rat thoracolumbar spinal cord MRI at 9.4 T.Magnetic resonance in medicine · 2023Article
- Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis.Scientific reports · 2023Article
- Brain Uptake of Folate Forms in the Presence of Folate Receptor Alpha Antibodies in Young Rats: Folate and Antibody Distribution.Nutrients · 2023Article
- Recent advances in arterial spin labeling perfusion MRI in patients with vascular cognitive impairment.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Review
- The role of the parenchymal vascular system in cerebrospinal fluid tracer clearance.European radiology · 2023Article
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- Perfusion-weighted software written in Python for DSC-MRI analysis.Frontiers in neuroinformatics · 2023Article
- Cytostatic hypothermia and its impact on glioblastoma and survival.Science advances · 2022Article
- Choroid plexus tissue perfusion and blood to CSF barrier function in rats measured with continuous arterial spin labeling.NeuroImage · 2022Article
- Quantitative chemical exchange saturation transfer imaging of nuclear overhauser effects in acute ischemic stroke.Magnetic resonance in medicine · 2022Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Cerebral blood flow is an important parameter in many diseases and functional studies that can be accurately measured in humans using arterial spin labelling (ASL) MRI. However, although rat models are frequently used for preclinical studies of both human disease and brain function, rat CBF measurements show poor consistency between studies. This lack of reproducibility is due, partly, to the smaller size and differing head geometry of rats compared to humans, as well as the differing analysis methodologies employed and higher field strengths used for preclinical MRI. To address these issues, we have implemented, optimised and validated a multiphase pseudo-continuous ASL technique, which overcomes many of the limitations of rat CBF measurement. Three rat strains (Wistar, Sprague Dawley and Berlin Druckrey IX) were used, and CBF values validated against gold-standard autoradiography measurements. Label positioning was found to be optimal at 45°, while post-label delay was optimised to 0.55 s. Whole brain CBF measures were 109 ± 22, 111 ± 18 and 100 ± 15 mL/100 g/min by multiphase pCASL, and 108 ± 12, 116 ± 14 and 122 ± 16 mL/100 g/min by autoradiography in Wistar, SD and BDIX cohorts, respectively. Tumour model analysis shows that the developed methods also apply in disease states. Thus, optimised multiphase pCASL provides robust, reproducible and non-invasive measurement of CBF in rats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.