Evidence map›Paper›PMID 29498513›Full record

ArticleAnalytical chemistry2018

Microfluidics-Based Chromosome Conformation Capture (3C) Technology for Examining Chromatin Organization with a Low Quantity of Cells.

Chen Sun, Chang Lu

Abstract read
In one paragraph

Article in Analytical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Funding

Probing dynamics in protein-DNA interactions during disease development using sinR01EB017235 · NIBIB · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI LU, CHANG · 2014 to 2017
$1.3M
Next-generation MOWChIP-seq for high-throughput epigenomic profiling using clinically relevant samplesR33CA214176 · NCI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI LU, CHANG · 2017 to 2019
$1.2M
Ultrasensitive microfluidic ChIP-MethylC-seq for integrative analysis of histone modification and DNA methylationR21HG009256 · NHGRI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI LU, CHANG · 2016 to 2018
$604k
NCI NIH HHS R33 CA214176NHGRI NIH HHS R21 HG009256NIBIB NIH HHS R01 EB017235
6 · The paper itself

Abstract

Detecting three-dimensional (3D) genome organization in the form of physical interactions between various genomic loci is of great importance for understanding transcriptional regulations and cellular fate. Chromosome Conformation Capture (3C) method is the gold standard for examining chromatin organization, but usually requires a large number of cells (>10

Indexed as

beta-GlobinsCell CountChromatinChromosomesDNAEquipment DesignHumansK562 CellsMicrofluidic Analytical TechniquesNucleic Acid Conformationbeta-GlobinsChromatinDNA

Identifiers

PMID29498513
PMCPMC5861017

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.