ArticleInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group2018
Thermal shock susceptibility and regrowth of Pseudomonas aeruginosa biofilms.
Article in International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Review
- Dispersion Inhibits Thermal Mitigation of Pseudomonas aeruginosa Biofilms on Self-Heating Surfaces.MicrobiologyOpen · 2026Article
- Alternating Magnetic Fields Remove Biofilms but Damage Cells on Implant Models Also with Negligible Bulk Heating.ACS applied materials & interfaces · 2025Article
- Biofilm Growth on Different Materials Used in Contemporary Femoral Head Prosthesis: An In Vitro Study.Journal of clinical medicine · 2025Article
- Antibiotic Augmentation of Thermal Eradication ofPathogens (Basel, Switzerland) · 2024Article
- Article
- Behavior of the Surviving Population ofFrontiers in microbiology · 2022Article
- Mesoporous TiOCatalysis letters · 2022Article
- Thermal Shock and Ciprofloxacin Act Orthogonally onAntibiotics (Basel, Switzerland) · 2021Article
- Alternating magnetic fields and antibiotics eradicate biofilm on metal in a synergistic fashion.NPJ biofilms and microbiomes · 2021Article
- Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Biofilms on implanted medical devices cause thousands of patients each year to undergo multiple surgeries to remove and replace the implant, driving billions of dollars in increased health care costs due to the lack of viable treatment options for in situ biofilm eradication. Remotely activated localised heating is under investigation to mitigate these biofilms; however, little is known about the temperatures required to kill the biofilms. To better understand the required parameters this study investigated the thermal susceptibility of biofilms as a function of their fluidic and chemical environment during growth, as well as their propensity for regrowth following thermal shock. Pseudomonas aeruginosa biofilms were cultured in shaker plate fluidic conditions in four different growth media, then thermally shocked at various temperatures and exposure times. Biofilms were re-incubated to determine their regrowth potential following thermal shocks of various intensities. Results indicate that growth media has little impact on thermal susceptibility, while fluidic conditions strongly influence susceptibility to modest thermal shocks. This effect disappears, however, with increasingly aggressive shocks, reducing biofilm populations by up to 5 orders of magnitude. Regrowth studies indicate a critical post-shock bacterial loading (∼10
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Registered trials
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