Evidence map›Paper›PMID 29498230›Full record

ArticleActa ophthalmologica2018

Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity.

Seiji Takagi, Yasuhiko Hirami, Masayo Takahashi, Masashi Fujihara, Michiko Mandai, Chisato Miyakoshi, Goji Tomita, Yasuo Kurimoto

Abstract read
In one paragraph

Article in Acta ophthalmologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Widefield OCT angiography.Progress in retinal and eye research · 2025
    Review
  6. Review
  7. Article
  8. Article
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  11. Optical coherence tomography angiography (OCT-A) in retinitis pigmentosa and macular dystrophy patients: a retrospective study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Article
  12. Optical coherence tomography angiography findings in patients undergoing transcorneal electrical stimulation for treating retinitis pigmentosa.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  13. The impact of macular edema on microvascular and metabolic alterations in retinitis pigmentosa.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  14. Artifacts and artifact removal in optical coherence tomographic angiography.Quantitative imaging in medicine and surgery · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Seiji TakagiDepartment of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan.ORCID http://orcid.org/0000-0001-6267-1641
Yasuhiko HiramiDepartment of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan.
Masayo TakahashiDepartment of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan.
Masashi FujiharaDepartment of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan.
Michiko MandaiDepartment of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan.
Chisato MiyakoshiDepartment of Pediatrics, Kobe City Medical Center General Hospital, Kobe, Japan.
Goji TomitaDepartment of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, Japan.
Yasuo KurimotoDepartment of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate flow area changes measured using optical coherence tomography angiography (OCTA; RTVue XR Avanti

methodsThis was an age- and refraction-matched case-control study. Consecutive patients with a best-corrected visual acuity (BCVA) of ≥20/20 and normal subjects were recruited. Fifty eyes (32 patients) and 22 eyes (12 controls) were included. The flow area and foveal avascular zone (FAZ) were measured in both superficial and deep layers within a 3 × 3 mm central area of the fovea. Association between OCTA parameters and the length of the inner segment ellipsoid (ISe) and external limiting membrane (ELM), the area without abnormal fluorescence in fundus autofluorescence (normal FAF area ratio) and the area of I-2e of the Goldmann perimeter were analysed using mixed-effects regression analysis.

resultsFoveal avascular zones were significantly smaller in patients with RP than in controls in superficial (p = 0.004) but not in deep layers (p = 0.25). The flow area in superficial (p = 0.007) and deep layers (p = 0.004) was significantly smaller in patients with RP than in controls. In patients with RP, flow areas in the superficial layers, but not in the deep layers, were significantly associated with the lengths of ISe (p = 0.001) and ELM (p = 0.002) and the I-2e area (p = 0.036), but not with the normal FAF area ratio (p = 0.399).

conclusionOptical coherence tomography angiography (OCTA)-measured flow area in superficial layers gradually reduced with RP progression and may be a useful parameter of RP pathogenesis.

Indexed as

FemaleFluorescein AngiographyFollow-Up StudiesFundus OculiHumansMaleMiddle AgedRetinaRetinitis PigmentosaRetrospective StudiesTomography, Optical CoherenceVisual Acuitycoefficient correlationinner segment ellipsoidoptical coherence tomography angiographyretinitis pigmentosa

Identifiers

PMID29498230
PMCPMC6175316

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.