ArticleObesity (Silver Spring, Md.)2018
Metabolically Healthy Obesity and Risk of Kidney Function Decline.
Article in Obesity (Silver Spring, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of body mass index on primary immunoglobulin A nephropathy prognosis: a systematic review and meta-analysis.International urology and nephrology · 2022Pooled it
- Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium.BMJ (Clinical research ed.) · 2019Pooled it
- Baseline and Follow-Up Association between Adiposity and Renal Function: Data from the ILERVAS Cohort.Obesity facts · 2026Article
- Obesity in Cardiorenal syndrome: Management Opportunities and Challenges.Current hypertension reports · 2025Review
- Anthropometric and Metabolic Determinants of Multi-Organ Stress in Adults with Obesity: Application of the CaRaMeL-O Score.Healthcare (Basel, Switzerland) · 2025Article
- Diabetic Kidney Disease: Evidence from Two Selected Cohorts of Patients from Low-Middle and High Income Countries.Life (Basel, Switzerland) · 2025Article
- Obesity and Metabolic Health in CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025Review
- Obesity-associated Inflammation and Alloimmunity.Transplantation · 2025Review
- Obesity, Metabolic Health, and Diabetic Complications in People With Type 1 Diabetes.Endocrinology, diabetes & metabolism · 2025Article
- Role of obesity in chronic kidney disease progression.Current research in physiology · 2025Review
- Relationships of Thickness of Perirenal Fat with Urinary Levels of MCP-1 and NGAL in Patients with Hypertension.Journal of obesity & metabolic syndrome · 2024Article
- The association between visceral adiposity index and decreased renal function: A population-based study.Frontiers in nutrition · 2023Article
- Association of Metabolically Healthy Obesity and Glomerular Filtration Rate among Male Steelworkers in North China.International journal of environmental research and public health · 2022Article
- Pathogenesis, Murine Models, and Clinical Implications of Metabolically Healthy Obesity.International journal of molecular sciences · 2022Review
- The Association of Excess Body Weight with Risk of ESKD Is Mediated Through Insulin Resistance, Hypertension, and Hyperuricemia.Journal of the American Society of Nephrology : JASN · 2022Article
- Metabolic obesity phenotypes and chronic kidney disease: a cross-sectional study from the RaNCD cohort study.BMC nephrology · 2022Article
- Association between TSH Values and GFR Levels in Euthyroid Cases with Metabolic Syndrome.International journal of endocrinology · 2021Article
- All-cause mortality in metabolically healthy individuals was not predicted by overweight and obesity.JCI insight · 2020Article
- The Association between Obesity Phenotypes and Early Renal Function Decline in Adults without Hypertension, Dyslipidemia, and Diabetes.Korean journal of family medicine · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveThe aim of this study was to examine the association between BMI categories, stratified by metabolic health status, and the risk of kidney function decline (KFD).
methodsIn this study, 42,128 adult patients with a stable BMI were classified over a 3-year baseline window by BMI and metabolic health status (assessed by Adult Treatment Panel-III criteria). KFD was defined as an estimated glomerular filtration rate (eGFR) decline ≥ 30%, eGFR < 15 mL/min/1.73 m
resultsOver a median of 5.1 years (interquartile range 2.1-8.9), 6,533 (15.5%) individuals developed KFD. Compared with the normal weight, metabolically healthy category, metabolically healthy obesity was associated with a higher risk of KFD (adjusted hazard ratio [aHR] 1.52; 95% CI: 1.22-1.89). aHRs for KFD were 1.17 (95% CI: 0.89-1.53), 2.21 (95% CI: 1.59-3.08), and 2.20 (95% CI: 1.55-3.11) for metabolically healthy obesity with BMI 30 to 34.9, BMI 35 to 39.9, and BMI ≥ 40 kg/m
conclusionsObesity, whether in the presence or absence of metabolic health, is a risk factor for KFD.
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