ArticleGeriatrics & gerontology international2018
Is anemia associated with cognitive impairment and delirium among older acute surgical patients?
Article in Geriatrics & gerontology international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Preoperative hemoglobin level and its relationship with mortality and adverse outcomes in older hip fracture patients from Qatar.BMC geriatrics · 2025Observational
- Association between preoperative anemia and postoperative delirium in elderly patients undergoing non-cardiac surgery: a retrospective observational study.Korean journal of anesthesiology · 2025Observational
- Observational
- Establishment and validation of a nomogram of postoperative delirium in patients undergoing cardiac surgery: a retrospective study of MIMIC-IV.BMC cardiovascular disorders · 2025Article
- The impact of perioperative anemia on postoperative delirium after hip fracture surgeries in older adults: a multicenter retrospective cohort study.Frontiers in nutrition · 2025Article
- Preoperative Anemia As a Predictor of Postoperative Delirium in Patients With Colorectal Cancer.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2025Article
- Association of anemia with postoperative cognitive decline and increased inflammatory markers in elderly gastrointestinal cancer patients.American journal of translational research · 2024Article
- A review of perioperative anemia: A modifiable and not so benign risk factor.Journal of family medicine and primary care · 2022Review
- Article
- Association of Anemia with Dementia and Cognitive Decline among Community-Dwelling Elderly.Gerontology · 2022Article
- Anemia and the Risk of Cognitive Impairment: An Updated Systematic Review and Meta-Analysis.Brain sciences · 2021Article
- Association between anemia, physical performance and cognitive function in Iranian elderly people: evidence from Bushehr Elderly Health (BEH) program.BMC geriatrics · 2021Article
- Hemoglobin Concentration and Post-Operative Delirium in Elderly Patients Undergoing Femoral Neck Fracture Surgery.Frontiers in medicine · 2021Article
- Article
- Pre-operative hemoglobin level and use of sedative-hypnotics are independent risk factors for post-operative delirium following total knee arthroplasty.BMC musculoskeletal disorders · 2020Article
- Cancer-Related Anemia Is a Risk Factor for Medium-Term Postoperative Cognitive Dysfunction in Laparoscopic Surgery Patients: An Observational Prospective Study.Neural plasticity · 2020Observational
- Red Cell Distribution Width Is Directly Associated with Poor Cognitive Performance among Nonanemic, Middle-Aged, Urban Adults.The Journal of nutrition · 2020Article
- Association between Anemia and Cognitive Impairment among Elderly Patients with Heart Failure.International journal of environmental research and public health · 2019Article
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Authors and funding
8 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe determinants of cognitive impairment and delirium during acute illness are poorly understood, despite being common among older people. Anemia is common in older people, and there is ongoing debate regarding the association between anemia, cognitive impairment and delirium, primarily in non-surgical patients.
methodsUsing data from the Older Persons Surgical Outcomes Collaboration 2013 and 2014 audit cycles, we examined the association between anemia and cognitive outcomes in patients aged ≥65 years admitted to five UK acute surgical units. On admission, the Confusion Assessment Method was carried out to detect delirium. Cognition was assessed using the Montreal Cognitive Assessment, and two levels of impairment were defined as Montreal Cognitive Assessment <26 and <20. Logistic regression models were constructed to examine these associations in all participants, and individuals aged ≥75 years only.
resultsA total of 653 patients, with a median age of 76.5 years (interquartile range 73.0-80.0 years) and 53% women, were included. Statistically significant associations were found between anemia and age; polypharmacy; hyperglycemia; and hypoalbuminemia. There was no association between anemia and cognitive impairment or delirium. The adjusted odds ratios of cognitive impairment were 0.95 (95% CI 0.56-1.61) and 1.00 (95% CI 0.61-1.64) for the Montreal Cognitive Assessment <26 and <20, respectively. The adjusted odds ratio of delirium was 1.00 (95% CI 0.48-2.10) in patients with anemia compared with those without. Similar results were observed for the ≥75 years age group.
conclusionsThere was no association between anemia and cognitive outcomes among older people in this acute surgical setting. Considering the retrospective nature of the study and possible lack of power, findings should be taken with caution. Geriatr Gerontol Int 2018; 18: 1025-1030.
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