Evidence map›Paper›PMID 29497980›Full record

SynthesisJournal of abnormal child psychology2019

Prevalence of Depressive Disorders in Individuals with Autism Spectrum Disorder: a Meta-Analysis.

Chloe C Hudson, Layla Hall, Kate L Harkness

2 registry-linked trialsAbstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of abnormal child psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 167 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05738967 nacompletednot on this mapstarted 2023, after this paper: background citation

Transdiagnostic Behavioral Therapy for Anxiety and Depression in Autistic Adolescents

TypeinterventionalSponsorBaylor College of MedicineRan2023 to 2025Enrolled47ConditionsAnxiety, Depression, Emotional Disorder, AutismArmsTransdiagnostic cognitive behavioral therapy (CBT), Treatment as usual
NCT07258914 narecruitingnot on this mapstarted 2024, after this paper: background citation

Feasibility and Efficacy of rTMS in Depression in Individuals With Autism Spectrum Disorder (ASD)

TypeinterventionalSponsorHospital Center Guillaume RégnierRan2024 to 2026Enrolled25ConditionsAutism Spectrum Disorder, Depression, Major Depressive Episode (MDE)ArmsrTMS, rTMS treatment with intermittent Theta Burst (ITBS)
3 · Its place in the literature

Who cites it

167 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Pooled it
  6. Trial
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  8. Depressive Symptoms in Autistic Youth with Anxiety Disorders.Journal of developmental and behavioral pediatrics : JDBP · 2023
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  13. Review
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  17. Observational
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107 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chloe C HudsonDepartment of Psychology, Queen's University, 62 Arch Street, Kingston, ON, K7L 3N6, Canada. c.hudson@queensu.ca.
Layla HallDepartment of Psychology, Queen's University, 62 Arch Street, Kingston, ON, K7L 3N6, Canada.
Kate L HarknessDepartment of Psychology, Queen's University, 62 Arch Street, Kingston, ON, K7L 3N6, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Substantial uncertainty exists about the prevalence of depressive disorders in individuals with autism spectrum disorder (ASD). This meta-analysis quantitatively summarized studies that assessed the lifetime and current prevalence of unipolar depressive disorders in children, adolescents, and adults with ASD. We also examined demographic, methodological, and study moderators. This meta-analysis adhered to PRISMA guidelines. A total of 7857 articles were identified through 5 databases (PubMed, Web of Science, PYSCInfo, CINAHL, ProQuest Dissertations and Theses), forward searches, and backward searches. Two reviewers independently screened articles and extracted data. Sixty-six articles met inclusion criteria. Results indicated that the pooled lifetime and current prevalence was 14.4% (95% CI 10.3-19.8) and 12.3% (95% CI 9.7-15.5), respectively. Rates of depressive disorders were highest among studies that used a standardized interview to assess depressive disorders (lifetime = 28.5%, 95% CI 20.1-38.8; current = 15.3%, 95% CI 11.0-20.9) and required participants to report on their own depressive symptoms (lifetime = 48.6%, 95% CI 33.3-64.2; current = 25.9%, 95% CI 17.0-37.3). Rates were also higher in studies that included participants with higher intelligence. Lifetime, but not current, prevalence was positively associated with age and the proportion of the sample that was White. In conclusion, we found that the rates of depressive disorders are high among individuals with ASD. Compared to typically developing individuals, individuals with ASD are 4-times more likely to experience depression in their lifetime. These results suggest that individuals with ASD should be regularly screened and offered treatment for depression.

Indexed as

ComorbidityAdolescentAdultAutism Spectrum DisorderChildChild, PreschoolDepressive DisorderHumansPrevalenceYoung AdultAutism spectrum disorderComorbidDepressive disordersMeta-analysisPrevalence

Identifiers

PMID29497980

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.