Evidence map›Paper›PMID 29497975›Full record

ArticleIrish journal of medical science2018

Plasma concentration of urokinase plasminogen activator receptor is a marker of kidney allograft function.

Marzena Staniszewska, Violetta Dziedziejko, Ewa Kwiatkowska, Marta Tkacz, Kamila Puchałowicz, Krzysztof Safranow, Leszek Domanski, Andrzej Pawlik

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Article in Irish journal of medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Marzena StaniszewskaDepartment of Physiology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111, Szczecin, Poland.
Violetta DziedziejkoDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111, Szczecin, Poland.
Ewa KwiatkowskaDepartment of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111, Szczecin, Poland.
Marta TkaczDepartment of Physiology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111, Szczecin, Poland.
Kamila PuchałowiczDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111, Szczecin, Poland.
Krzysztof SafranowDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111, Szczecin, Poland.
Leszek DomanskiDepartment of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111, Szczecin, Poland.
Andrzej PawlikDepartment of Physiology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111, Szczecin, Poland. pawand@poczta.onet.pl.
Pomeranian Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUrokinase-type plasminogen activator receptor (uPAR) is found in a variety of cell types including monocytes, lymphocytes, macrophages, and endothelial cells and plays an important role in fibrinolysis and in the activation and chemotaxis of neutrophils and lymphocytes. In this study, we examined the correlation between uPAR plasma concentration and kidney allograft function.

aimsThis study enrolled 78 Caucasian deceased-donor renal transplant recipients.

methodsPlasma concentrations of uPAR were measured using commercially available enzyme-linked immunosorbent assay (ELISA) kits.

resultsWe observed elevated with borderline significance (p = 0.095) uPAR plasma concentrations in patients with tubular atrophy. Plasma concentrations of uPAR showed strong statistically significant positive correlations with serum creatinine or urea and strong negative correlation with estimated glomerular filtration rate (eGFR). There was also a borderline positive correlation between uPAR plasma concentration and protein concentration in urine as well as the duration of hemodialysis.

conclusionsThe results of our study indicate that uPAR plasma concentrations in kidney allograft recipients are significantly negatively correlated with graft function and may be elevated in patients with tubular atrophy.

Indexed as

Kidney TransplantationAllograftsBiomarkersEnzyme-Linked Immunosorbent AssayFemaleGraft SurvivalHumansKidneyMaleMiddle AgedReceptors, Urokinase Plasminogen ActivatorSignal TransductionBiomarkersReceptors, Urokinase Plasminogen ActivatorAcute rejectionDelayed graft functionRenal transplantationUrokinase-type plasminogen activator receptor (uPAR)

Identifiers

PMID29497975
OpenAlexW2789731701

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.