Evidence map›Paper›PMID 29497963›Full record

Trial reportJournal of cancer survivorship : research and practice2018

Long-term effectiveness and cost-effectiveness of high versus low-to-moderate intensity resistance and endurance exercise interventions among cancer survivors.

C S Kampshoff, J M van Dongen, W van Mechelen, G Schep, A Vreugdenhil, J W R Twisk, J E Bosmans, J Brug, M J M Chinapaw, Laurien M Buffart

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cancer survivorship : research and practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05067777 (Massage for Prostate Cancer-Related Fatigue), which is not on this map. Cited by 30 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05067777 phase2terminatednot on this mapstarted 2022, after this paper: background citation

Massage for Prostate Cancer-Related Fatigue (mPROSTATE)

TypeinterventionalSponsorUniversity of UtahRan2022 to 2025Enrolled28ConditionsProstate CarcinomaArmsSwedish Massage Therapy (SMT), Light Touch (LT) Control, Waitlist Control (WLC)
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
  2. Management of Fatigue in Adult Survivors of Cancer: ASCO-Society for Integrative Oncology Guideline Update.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Guideline
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  4. High-intensity interval training effects in cardiorespiratory fitness of lung cancer survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

C S KampshoffDepartment of Public & Occupational Health, and the Amsterdam Public Health research institute, VU University Medical Center, Amsterdam, The Netherlands.
J M van DongenDepartment of Health Sciences and the Amsterdam Public Health research institute, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
W van MechelenDepartment of Public & Occupational Health, and the Amsterdam Public Health research institute, VU University Medical Center, Amsterdam, The Netherlands.
G SchepDepartment of Sports Medicine, Máxima Medical Center, Veldhoven, The Netherlands.
A VreugdenhilMáxima Oncology Center, Eindhoven and Veldhoven, The Netherlands.
J W R TwiskDepartment of Epidemiology and Biostatistics, and the Amsterdam Public Health research institute, VU University Medical Center, De Boelelaan 1089a, 1081, HV, Amsterdam, The Netherlands.
J E BosmansDepartment of Health Sciences and the Amsterdam Public Health research institute, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
J BrugDepartment of Epidemiology and Biostatistics, and the Amsterdam Public Health research institute, VU University Medical Center, De Boelelaan 1089a, 1081, HV, Amsterdam, The Netherlands.
M J M ChinapawDepartment of Public & Occupational Health, and the Amsterdam Public Health research institute, VU University Medical Center, Amsterdam, The Netherlands.
Laurien M BuffartDepartment of Epidemiology and Biostatistics, and the Amsterdam Public Health research institute, VU University Medical Center, De Boelelaan 1089a, 1081, HV, Amsterdam, The Netherlands. l.buffart@vumc.nl.

Funding

Alpe d'HuZes/KWF Fund provided by the Dutch Cancer Society ALPE2009-4619
6 · The paper itself

Abstract

purposeThis study aimed to evaluate the long-term effectiveness and cost-effectiveness of high intensity (HI) versus low-to-moderate intensity (LMI) exercise on physical fitness, fatigue, and health-related quality of life (HRQoL) in cancer survivors.

methodsTwo hundred seventy-seven cancer survivors participated in the Resistance and Endurance exercise After ChemoTherapy (REACT) study and were randomized to 12 weeks of HI (n = 139) or LMI exercise (n = 138) that had similar exercise types, durations, and frequencies, but different intensities. Measurements were performed at baseline (4-6 weeks after primary treatment), and 12 (i.e., short term) and 64 (i.e., longer term) weeks later. Outcomes included cardiorespiratory fitness, muscle strength, self-reported fatigue, HRQoL, quality-adjusted life years (QALYs) and societal costs. Linear mixed models were conducted to study (a) differences in effects between HI and LMI exercise at longer term, (b) within-group changes from short term to longer term, and (c) the cost-effectiveness from a societal perspective.

resultsAt longer term, intervention effects on role (β = 5.9, 95% CI = 0.5; 11.3) and social functioning (β = 5.7, 95%CI = 1.7; 9.6) were larger for HI compared to those for LMI exercise. No significant between-group differences were found for physical fitness and fatigue. Intervention-induced improvements in cardiorespiratory fitness and HRQoL were maintained between weeks 12 and 64, but not for fatigue. From a societal perspective, the probability that HI was cost-effective compared to LMI exercise was 0.91 at 20,000€/QALY and 0.95 at 52,000€/QALY gained, mostly due to significant lower healthcare costs in HI exrcise.

conclusionsAt longer term, we found larger intervention effects on role and social functioning for HI than for LMI exercise. Furthermore, HI exercise was cost-effective with regard to QALYs compared to LMI exercise.

trial registrationThis study is registered at the Netherlands Trial Register [NTR2153 [ http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2153 ]] on the 5th of January 2010. IMPLICATIONS FOR CANCER SURVIVORS: Exercise is recommended to be part of standard cancer care, and HI may be preferred over LMI exercise.

Indexed as

Cancer SurvivorsEndurance TrainingExercise TherapyResistance TrainingAdultCardiorespiratory FitnessCost-Benefit AnalysisFatigueFemaleHealth Care CostsHumansMaleMiddle AgedMuscle StrengthNetherlandsPhysical FitnessCost-effectivenessExercise intensityFatigueNeoplasmsPhysical fitnessQuality of life

Identifiers

PMID29497963
PMCPMC5956032

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.