Evidence map›Paper›PMID 29497942›Full record

ArticleEnvironmental science and pollution research international2018

Is there any association between phthalate exposure and precocious puberty in girls?

Mahin Hashemipour, Roya Kelishadi, Mohammad Mehdi Amin, Karim Ebrahim

Abstract read
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In one paragraph

Article in Environmental science and pollution research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
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  11. Medication-Associated Phthalate Exposure and Childhood Cancer Incidence.Journal of the National Cancer Institute · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mahin HashemipourEndocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Roya KelishadiChild Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohammad Mehdi AminDepartment of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Hezar-Jarib Avenue, Isfahan, 81745-185, Iran.
Karim EbrahimDepartment of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Hezar-Jarib Avenue, Isfahan, 81745-185, Iran. k.najafabady@sbmu.ac.ir.ORCID http://orcid.org/0000-0002-6230-0119
Isfahan University of Medical Sciences · IR

Funding

Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran (Research project No. 194151)
6 · The paper itself

Abstract

Considerable increase in the prevalence of precocious puberty (PP) during the last decade has raised a lot of concerns. Some environmental endocrine disruptor chemicals (EDCs), such as phthalate esters, have intrinsic estrogen activity or increase endogenous sex hormone levels leading to PP. This study was conducted to investigate the association between exposure to phthalate esters and PP in a sample of girls. Plasma levels of seven phthalate ester metabolites were measured in 87 girls with PP and 63 age- and sex-matched controls by dispersive liquid-liquid microextraction and GC/MS analysis. History of exposure to main sources of phthalates was obtained by a checklist. Diethyl hexyl phthalate (DEHP) metabolite levels were significantly higher in those with PP than that in controls (p < 0.05), but this difference was not significant for other phthalate metabolites. 30.1% girls with PP and 12.2% of controls had played for more than 2 h/day with plastic toys in their childhood. 65.1% girls with PP and 32.8% of controls have regularly used some cosmetic products. Consumption of bottled water and beverages by those with PP was about twofold higher than that in the control group. A positive correlation was found between bottled ware consumption and plasma concentrations of four phthalate metabolites. The frequency of seafood consumption was not significantly different between the groups studied. Our findings confirm positive association between phthalate exposure and incidence of PP in girls. Control and reduction of children exposure to phthalate esters should be considered as a health priority.

Indexed as

Phthalic AcidsCosmeticsDiethylhexyl PhthalateDrinking WaterEndocrine DisruptorsEnvironmental ExposureEstersFemaleGas Chromatography-Mass SpectrometryHumansPuberty, PrecociousCosmeticsDiethylhexyl PhthalateDrinking WaterEndocrine DisruptorsEstersphthalic acidPhthalic AcidsEndocrine disruptor chemicalsGirlsPhthalate estersPrecocious pubertyReproductive system

Identifiers

PMID29497942
OpenAlexW2791846435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.