ReviewReviews in endocrine & metabolic disorders2018
Hyperammonemia and lactic acidosis in adults: Differential diagnoses with a focus on inborn errors of metabolism.
Review in Reviews in endocrine & metabolic disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Relationship between the incidence of non-hepatic hyperammonemia and the prognosis of patients in the intensive care unit.World journal of gastroenterology · 2020Trial
- Nitric Oxide Synthase Dysregulation in Hyperammonemia: Opportunities and Challenges Toward Therapeutic Targeting to Combat Neurological Complications.Neurochemical research · 2026Review
- Testing of a novel automated point-of-care analyzer for blood ammonium monitoring in a clinical setting.Analytical and bioanalytical chemistry · 2025Article
- Prognostic value of serum ammonia in critical patients with non-hepatic disease: A prospective, observational, multicenter study.Journal of translational internal medicine · 2023Article
- Hyperammonemia in Inherited Metabolic Diseases.Cellular and molecular neurobiology · 2022Review
- Diagnosis and Management of Inborn Errors of Metabolism in Adult Patients in the Emergency Department.Diagnostics (Basel, Switzerland) · 2021Review
- Approach to the interpretation of unexpected laboratory results arising in the care of patients with inborn errors of metabolism (IEM).Reviews in endocrine & metabolic disorders · 2018Review
- Impact of pregnancy on inborn errors of metabolism.Reviews in endocrine & metabolic disorders · 2018Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adult endocrinologist may be asked to consult on a patient for unexplained biochemical disturbances that could be caused by an underlying inborn error of metabolism. A genetic disorder is generally less likely to be the cause as these disorders are individually rare, however inborn errors of metabolism are collectively not infrequent and important to consider as they may be treatable and tragic outcomes avoided. Hyperammonemia or lactic acidosis are most often secondary markers of an acquired primary disease process, but they may be a clue to the presence of a genetic disorder. Herein is presented an approach to the differential diagnosis of elevated ammonia and lactate, and a brief discussion of management for when an inborn error is diagnosed.
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