ArticleCytotechnology2018
Anti-inflammatory effect of lysozyme from hen egg white on mouse peritoneal macrophages.
Article in Cytotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Comparative genomics reveals immunomodulatory and anti-obesity traits of Lactococcus lactis subsp. lactis.Applied microbiology and biotechnology · 2026Article
- Lysozyme as a natural feed additive in poultry and rabbit production: implications for growth, health and sustainability - a review.Tropical animal health and production · 2026Review
- Lysozyme Functionalized Alginate-Chitosan Beads and Films for Different Release Applications.Gels (Basel, Switzerland) · 2026Article
- Lysozyme and dandelion extract alleviate tearing eye disease by reducing inflammation and oxidative stress through canine corneal fibroblast model established.Veterinary research communications · 2025Article
- Enzyme-Based Anti-Inflammatory Therapeutics for Inflammatory Diseases.Pharmaceutics · 2025Review
- Postbiotic, anti-inflammatory, and immunomodulatory effects of aqueous microbial lysozyme in broiler chickens.Animal biotechnology · 2024Article
- Formation and Applications of Typical Basic Protein-Based Heteroprotein Complex Coacervations.Foods (Basel, Switzerland) · 2024Review
- Article
- Is there sufficient evidence to support the health benefits of including donkey milk in the diet?Frontiers in nutrition · 2024Review
- Hen egg white bovine colostrum supplement reduces symptoms of mild/moderate COVID-19: a randomized control trial.Future science OA · 2023Article
- Pharmacological Modulation of Host Immunity with Hen Egg White Lysozyme (HEWL)-A Review.Molecules (Basel, Switzerland) · 2023Review
- Lysozyme and Its Application as Antibacterial Agent in Food Industry.Molecules (Basel, Switzerland) · 2022Review
- Chemical Barrier Proteins in Human Body Fluids.Biomedicines · 2022Review
- Non-interventional Pilot Study Evaluating the Efficacy and Safety of Lysozymebased Therapy in Patients with Non-infectious Sore Throat.Acta medica academica · 2022Article
- Ovotransferrin exerts bidirectional immunomodulatory activities via TLR4-mediated signal transduction pathways in RAW264.7 cells.Food science & nutrition · 2021Article
- Recent Insights Into the Prognostic and Therapeutic Applications of Lysozymes.Frontiers in pharmacology · 2021Review
- Lysozyme in the treatment of non-infectious sore throat.Bosnian journal of basic medical sciences · 2020Article
- Lysozyme-Induced Transcriptional Regulation of TNF-α Pathway Genes in Cells of the Monocyte Lineage.International journal of molecular sciences · 2019Article
- Anti-inflammatory effect of aqueous extract from Kawachi-bankan (Citrus maxima) peel in vitro and in vivo.Cytotechnology · 2019Article
- Lysozyme from hen egg white ameliorates lipopolysaccharide-induced systemic inflammation in mice.Cytotechnology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Lysozyme from hen egg has been reported to possess an anti-inflammatory effect. However, little is known about its detailed mechanism. The mechanism of anti-inflammatory effect of lysozyme was examined in this study. When mouse macrophage-like cell line RAW264.7 cells and mouse peritoneal macrophages were activated with lipopolysaccharide (LPS) and then treated with lysozyme, the production of tumor necrosis factor-α and interleukin-6 was significantly suppressed. The effect was induced by suppressing the gene expression levels of both cytokines. Phagocytosis activity of peritoneal macrophages was not altered by the treatment with lysozyme, suggesting that lysozyme shows the anti-inflammatory effect without inhibiting the phagocytotic response of macrophages. In addition, lysozyme inhibited phosphorylation of c-jun N-terminal kinase (JNK) and was taken up by macrophages within 1 h after treatment of the cells with lysozyme. Overall results suggest that lysozyme is taken up intracellularly and suppresses LPS-induced inflammatory responses by inhibiting JNK phosphorylation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.