ReviewPediatric nephrology (Berlin, Germany)2019
Acute kidney injury in children with chronic liver disease.
Review in Pediatric nephrology (Berlin, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Terlipressin in paediatric hepatorenal syndrome-acute kidney injury (HRS-AKI).Pediatric nephrology (Berlin, Germany) · 2026Review
- Nomogram for predicting myocardial injury in pediatric patients undergoing living donor liver transplantation for biliary atresia.World journal of gastrointestinal surgery · 2025Article
- Optimizing kidney health following pediatric liver transplantation: current challenges and future directions.Pediatric nephrology (Berlin, Germany) · 2025Article
- Intraoperative kidney replacement therapy in acute liver failure.Pediatric nephrology (Berlin, Germany) · 2024Review
- Acute kidney injury in patients with cirrhosis: Acute Disease Quality Initiative (ADQI) and International Club of Ascites (ICA) joint multidisciplinary consensus meeting.Journal of hepatology · 2024Review
- Systemic Complications Secondary to Chronic Liver Disease.Indian journal of pediatrics · 2024Review
- Transient elastography and von Willebrand factor as predictors of portal hypertension and decompensation in children.JHEP reports : innovation in hepatology · 2023Article
- Preserved renal function during long-term follow-up in children with chronic liver disease.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Blood Urea Nitrogen to Serum Albumin Ratio in the Prediction of Acute Kidney Injury of Patients with Rib Fracture in Intensive Care Unit.International journal of general medicine · 2022Article
- Continuous Renal Replacement Therapy in Pediatric Patients With Acute Kidney Injury After Liver Transplantation.Frontiers in pediatrics · 2022Article
- Multiple organ involvement and ICU considerations for the care of acute liver failure (ALF) and acute on chronic liver failure (ACLF) in children.Translational pediatrics · 2021Review
- Hepatorenal syndrome in children: a review.Pediatric nephrology (Berlin, Germany) · 2021Review
- Advances in management of end stage liver disease in children.Medical journal, Armed Forces India · 2021Review
- PCRRT Expert Committee ICONIC Position Paper on Prescribing Kidney Replacement Therapy in Critically Sick Children With Acute Liver Failure.Frontiers in pediatrics · 2021Article
- LCAT protects against Lipoprotein-X formation in a murine model of drug-induced intrahepatic cholestasis.Pharmacology research & perspectives · 2020Article
- Clinically Evident Portal Hypertension: An Operational Research Definition for Future Investigations in the Pediatric Population.Journal of pediatric gastroenterology and nutrition · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) is a common accompaniment in patients with liver disease. The causes, risk factors, manifestations and management of AKI in these patients vary according to the liver disease in question (acute liver failure, acute-on-chronic liver failure, post-liver transplantation or metabolic liver disease). There are multiple causes of AKI in patients with liver disease-pre-renal, acute tubular necrosis, post-renal, drug-induced renal failure and hepatorenal syndrome (HRS). Definitions of AKI in liver failure are periodically revised and updated, but pediatric definitions have still to see the light of the day. As our understanding of the pathophysiology of liver disease and renal involvement improves, treatment modalities have become more advanced and rationalized. Treatment includes reversing precipitating factors, such as infections and gastrointestinal bleeding, volume expansion, paracentesis and vasoconstrictors. This approach is tried and tested in adults. A pediatric tailored approach is still lacking due to inadequate numbers of patients, differences in causes of AKI and paucity of literature. In this review, we attempt to explore the pathophysiological basis, treatment modalities and controversies in the diagnosis and treatment of AKI in pediatric patients with chronic liver disease and discuss our own personal practice. We recognize that, although it is not a very commonly encountered entity in pediatric population, HRS has specific diagnostic criteria and treatment modalities that differ from other causes of AKI in patients with chronic liver disease; hence among the etiologies of kidney injury in patients with chronic liver disease, we focus here on HRS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.