Evidence map›Paper›PMID 29497630›Full record

ArticleCellR4-- repair, replacement, regeneration, & reprogramming2013

A NATURAL BODY WINDOW TO STUDY HUMAN PANCREATIC ISLET CELL FUNCTION AND SURVIVAL.

M H Abdulreda, A Caicedo, P-O Berggren

Abstract read
In one paragraph

Article in CellR4-- repair, replacement, regeneration, & reprogramming, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Fluorescence imaging of beta cell primary cilia.Frontiers in endocrinology · 2022
    Article
  6. Review
  7. Comparative transcriptomics in human and mouse.Nature reviews. Genetics · 2017
    Review
  8. Clinical intraocular islet transplantation is not a number issue.CellR4-- repair, replacement, regeneration, & reprogramming · 2016
    Article
  9. Intravital imaging of cytotoxic T lymphocytes.Methods in molecular biology (Clifton, N.J.) · 2014
    Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

M H AbdulredaDiabetes Research Institute, Diabetes Research Institute Federation Center at the University of Miami Miller School of Medicine, Miami, FL, USA.
A CaicedoDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
P-O BerggrenDiabetes Research Institute, Diabetes Research Institute Federation Center at the University of Miami Miller School of Medicine, Miami, FL, USA.

Funding

Multi-Disciplinary Approaches to Driving Therapeutic Human Beta Cell ReplicationU01DK089538 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STEWART, ANDREW F. · 2010 to 2014
$3.6M
The Role of Innervation for Hormone Secretion in Human IsletsR01DK084321 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CAICEDO, ALEJANDRO · 2011 to 2015
$1.8M
Role of macrophages in pancreatic islet graft rejectionK01DK097194 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ABDULREDA, MIDHAT H · 2013 to 2015
$415k
The Role of Innervation for Hormone Secretion in Human IsletsR56DK084321 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CAICEDO, ALEJANDRO · 2009 to 2016
$306k
Glutamate Signaling in Human Islets of LangerhansR03DK075487 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CAICEDO VIERKANT, ALEJANDRO · 2006 to 2007
$301k
Noninvasive two-photon imaging of pancreatic islet graft rejection in the eyeF32DK083226 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ABDULREDA, MIDHAT H · 2009 to 2011
$151k
NIDDK NIH HHS F32 DK083226NIDDK NIH HHS K01 DK097194NIDDK NIH HHS R01 DK084321NIDDK NIH HHS R03 DK075487NIDDK NIH HHS R56 DK084321NIDDK NIH HHS U01 DK089538
6 · The paper itself

Abstract

The World Health Organization projects diabetes prevalence worldwide to be at 4.4% in 2030 compared to 2.8% in the year 2000. These alarming predictions come amid vigorous efforts in diabetes research which have failed so far to deliver effective therapies. Our incomplete understanding of the pathogenesis of diabetes is likely to contribute to the "disconnect" between our research efforts and their translation into successful therapies. Technically, studying the pathophysiology of the pancreatic islets is hindered by the anatomical location of the pancreas, which is deeply embedded in the body, and by lack of experimental tools that enable comprehensive interrogation of the pancreatic islets with sufficient resolution in the context of the natural

Indexed as

DiabetesHuman pancreatic islet cellin vivo imagingIslets of Langerhans

Identifiers

PMID29497630
PMCPMC5828509

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.