Evidence map›Paper›PMID 29497601›Full record

ArticleFrontiers in cellular and infection microbiology2018

Ecological Shifts of Supragingival Microbiota in Association with Pregnancy.

Wenzhen Lin, Wenxin Jiang, Xuchen Hu, Li Gao, Dongmei Ai, Hongfei Pan, Chenguang Niu, Keyong Yuan, Xuedong Zhou, Changen Xu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Characterizing the supragingival microbiome of healthy pregnant women.Frontiers in cellular and infection microbiology · 2022
    Trial
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Hormonal Environment Shapes the Oral Microbiome.Advances in experimental medicine and biology · 2025
    Review
  13. Dynamic changes in the pregnancy microbiome and their role in preterm birth.Frontiers in cellular and infection microbiology · 2025
    Review
  14. Review
  15. Article
  16. Article
  17. Observational
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Wenzhen LinDepartment of Endodontics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wenxin JiangDepartment of Endodontics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xuchen HuDepartment of Endodontics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Li GaoDepartment of Endodontics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dongmei AiDepartment of Information and Computational Sciences, University of Science and Technology Beijing, Beijing, China.
Hongfei PanDepartment of Information and Computational Sciences, University of Science and Technology Beijing, Beijing, China.
Chenguang NiuDepartment of Endodontics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Keyong YuanDepartment of Endodontics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xuedong ZhouState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Changen XuObstetrics Department, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Zhengwei HuangDepartment of Endodontics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Jiao Tong University · CNShanghai Ninth People's Hospital · CNBeijing Information Science & Technology University · CNObstetrics and Gynecology Hospital of Fudan University · CNSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregnancy is a physiological process with pronounced hormonal fluctuations in females, and relatively little is known regarding how pregnancy influences the ecological shifts of supragingival microbiota. In this study, supragingival plaques and salivary hormones were collected from 11 pregnant women during pregnancy (P1, ≤14 weeks; P2, 20-25 weeks; P3, 33-37 weeks) and the postpartum period (P4, 6 weeks after childbirth). Seven non-pregnant volunteers were sampled at the same time intervals. The microbial genetic repertoire was obtained by 16S rDNA sequencing. Our results indicated that the Shannon diversity in P3 was significantly higher than in the non-pregnant group. The principal coordinates analysis showed distinct clustering according to gestational status, and the partial least squares discriminant analysis identified 33 genera that may contribute to this difference. There were differentially distributed genera, among which

Indexed as

BiodiversityMicrobiotaAdultFemaleGingivaHormonesHumansMetagenomeMetagenomicsPhylogenyPregnancyRNA, Ribosomal, 16SSalivaHormonesRNA, Ribosomal, 16S16S rDNA sequencingbacterial diversityfemale steroid hormonesoral microbiotapregnancysupragingival plaque

Identifiers

PMID29497601
PMCPMC5819318
OpenAlexW2794205287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.