Evidence map›Paper›PMID 29497423›Full record

ArticleFrontiers in immunology2018

Whole-Genome Expression Profiling in Skin Reveals SYK As a Key Regulator of Inflammation in Experimental Epidermolysis Bullosa Acquisita.

Unni K Samavedam, Nina Mitschker, Anika Kasprick, Katja Bieber, Enno Schmidt, Tamás Laskay, Andreas Recke, S Goletz, Gestur Vidarsson, Franziska S Schulze and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  6. New small molecules in dermatology: for the autoimmunity, inflammation and beyond.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
  7. Article
  8. Article
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  10. Review
  11. Article
  12. Article
  13. Article
  14. Drug Development in Pemphigoid Diseases.Acta dermato-venereologica · 2020
    Review
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Unni K SamavedamDepartment of Dermatology, University of Lübeck, Lübeck, Germany.
Nina MitschkerDepartment of Dermatology, University of Lübeck, Lübeck, Germany.
Anika KasprickLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Katja BieberLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Enno SchmidtDepartment of Dermatology, University of Lübeck, Lübeck, Germany.
Tamás LaskayInstitute for Medical Microbiology and Hygiene, University of Lübeck, Lübeck, Germany.
Andreas ReckeDepartment of Dermatology, University of Lübeck, Lübeck, Germany.
S GoletzLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Gestur VidarssonDepartment of Experimental Hematology, Sanquin Research Institute, Amsterdam, Netherlands.
Franziska S SchulzeLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Mikko ArmbrustLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Katharina Schulze DieckhoffLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Hendri H PasCenter for Blistering Diseases, Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Marcel F JonkmanCenter for Blistering Diseases, Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Kathrin KaliesInstitute of Anatomy, University of Lübeck, Lübeck, Germany.
Detlef ZillikensDepartment of Dermatology, University of Lübeck, Lübeck, Germany.
Yask GuptaDepartment of Dermatology, University of Lübeck, Lübeck, Germany.
Saleh M IbrahimDepartment of Dermatology, University of Lübeck, Lübeck, Germany.
Ralf J LudwigDepartment of Dermatology, University of Lübeck, Lübeck, Germany.
University of Lübeck · DESanquin · NLUniversity Medical Center Groningen · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Because of the morbidity and limited therapeutic options of autoimmune diseases, there is a high, and thus far, unmet medical need for development of novel treatments. Pemphigoid diseases, such as epidermolysis bullosa acquisita (EBA), are prototypical autoimmune diseases that are caused by autoantibodies targeting structural proteins of the skin, leading to inflammation, mediated by myeloid cells. To identify novel treatment targets, we performed cutaneous genome-wide mRNA expression profiling in 190 outbred mice after EBA induction. Comparison of genome-wide mRNA expression profiles in diseased and healthy mice, and construction of a co-expression network identified

Indexed as

Aged, 80 and overAnimalsAutoimmune DiseasesBiopsyCase-Control StudiesDisease Models, AnimalEpidermolysis Bullosa AcquisitaFemaleGene Expression ProfilingHumansMaleMiceMice, Inbred C57BLMyeloid CellsProtein Interaction MapsSkinSyk KinaseSYK protein, humanSyk protein, mouseanimal modelsautoimmunityepidermolysis bullosa acquisitapemphigoidsignal transductionskinspleen tyrosine kinasetreatment

Identifiers

PMID29497423
PMCPMC5818881
OpenAlexW2789322949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.