Trial reportInternational journal of chronic obstructive pulmonary disease2018
Seasonal variations in exacerbations and deaths in patients with COPD during the TIOSPIR
Trial report in International journal of chronic obstructive pulmonary disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01126437 (A Randomized, Active-controlled, Double-blind, Double-dummy, Parallel Group Design, Multi-center Trial to Compare the Efficacy and Safety of 2.5 µg and 5 µg Tiotropium Inhalation Solution Delivered by the Respimat Inhaler With Tiotropium Inhalation Capsules 18 µg Delivered by the HandiHaler), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Active-controlled, Double-blind, Double-dummy, Parallel Group Design, Multi-center Trial to Compare the Efficacy and Safety of 2.5 µg and 5 µg Tiotropium Inhalation Solution Delivered by the Respimat Inhaler With Tiotropium Inhalation Capsules 18 µg Delivered by the HandiHaler (TIOSPIR)
Who cites it
19 citing papers in PubMed.
- Impact of a Heating Voucher on Health Outcomes in COPD Patients: A Randomised Controlled Trial.International journal of chronic obstructive pulmonary disease · 2025Trial
- SWORD survey: Seasonal trends in hospitalisation and mortality among patients with respiratory illnesses in India.Lung India : official organ of Indian Chest Society · 2026Article
- Barriers to and enablers of physical activity and its association with daily steps after hospitalisation for a COPD exacerbation: what patients say matters.ERJ open research · 2025Article
- Post-pandemic seasonal dynamics of hospitalised COPD exacerbations and aetiologies in the COPD population.ERJ open research · 2024Article
- COPD Exacerbations Before and During COVID-19 in France, Germany, Italy, the UK and the US.International journal of chronic obstructive pulmonary disease · 2024Article
- Trends, seasonal variations and forecasting of chronic respiratory disease morbidity in charcoal producing areas, northwest Ethiopia: time series analysis.Frontiers in epidemiology · 2024Article
- Ambient temperature and seasonal variation in inpatient mortality from respiratory diseases: a retrospective observational study.The Lancet regional health. Europe · 2023Article
- Impact of Coronavirus Disease 2019-Related Infection Prevention and Control Measures on the Occurrence of COPD Exacerbations During Inpatient Pulmonary Rehabilitation.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2023Article
- Observational
- Seasonal variations of patients presenting dyspnea to emergency departments in Europe: Results from the EURODEM StudyTurkish journal of medical sciences · 2020Observational
- Emergency department visits and hospitalisations for asthma, COPD and respiratory tract infections: what is the role of respiratory viruses, and return to school in September, January and March?ERJ open research · 2020Article
- Definition, Causes, Pathogenesis, and Consequences of Chronic Obstructive Pulmonary Disease Exacerbations.Clinics in chest medicine · 2020Review
- Trends and seasonal variation of hospitalization and mortality of interstitial lung disease in the United States from 2006 to 2016.Respiratory research · 2020Article
- Diagnosis and management of chronic obstructive pulmonary disease in Serbia: an expert group position statement.International journal of chronic obstructive pulmonary disease · 2019Review
- The Impact of Air Pollution, Including Asian Sand Dust, on Respiratory Symptoms and Health-related Quality of Life in Outpatients With Chronic Respiratory Disease in Korea: A Panel Study.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2018Article
- A time for everything and everything in its time - exploring the mechanisms underlying seasonality of COPD exacerbations.International journal of chronic obstructive pulmonary disease · 2018Review
- Real-time experience of an acute exacerbation of COPD: A qualitative exploration.Chronic respiratory diseaseArticle
- Predicting Re-Exacerbation Timing and Understanding Prolonged Exacerbations: An Analysis of Patients with COPD in the ECLIPSE Cohort.International journal of chronic obstructive pulmonary diseaseArticle
- Mortality, seasonal variation, and susceptibility to acute exacerbation of COPD in the pandemic year: a nationwide population study.Therapeutic advances in respiratory diseaseArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Although COPD exacerbations are known to occur more frequently in winter, there is little information on hospitalizations and cause-specific mortality. This study aimed to examine seasonal variations in mortality and exacerbations in patients with COPD during the TIOtropium Safety and Performance In Respimat Patients and methods: TIOSPIR was a large-scale, multicenter trial, which assessed the safety and efficacy of tiotropium delivered via HandiHaler Results: TIOSPIR was conducted in 43 northern (n=15,968) and 7 southern (n=1,148) hemisphere (n=1,148) countries. The median duration of treatment was 835 days, with a mean follow-up of 2.3 years. Among 19,494 exacerbations, there were clear seasonal differences (winter, 6,646 [34.1%]; spring, 4,515 [23.2%]; summer, 3,198 [16.4%]; autumn, 5,135 [26.3%]). Exacerbations peaked in early winter (December in the northern hemisphere and June in the southern hemisphere), respiratory hospitalizations in midwinter, and respiratory deaths in early spring. Conclusion: Although winter poses a 2-fold hazard for COPD exacerbations vs summer, respiratory deaths peak in early spring. These data suggest that seasonal intensification of preventive treatments may impact COPD morbidity and mortality. Trial registration number: NCT01126437.
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