ReviewIndian journal of palliative care2018
Practical Pharmacology of Methadone: A Long-acting Opioid.
Review in Indian journal of palliative care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07092475 (The Impact of Intraoperative Methadone on Postoperative Opioid Use), which is not on this map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Intraoperative Methadone on Postoperative Opioid Use
Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Implementation and Results of Intraoperative Methadone in Pediatric Cardiac Surgery: Early Experiences and Outcomes.World journal for pediatric & congenital heart surgery · 2026Article
- Fatty Acid-Binding Proteins and Substance Use Disorders: From Lipid Signaling to Therapeutic Targets.Genes · 2026Review
- Pharmacologic and toxicologic confounders in brain death determination: a multidisciplinary guide.Critical care (London, England) · 2026Review
- Opioid dependence in patients with pain in chronic pancreatitis an emerging problem.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Review
- Methadone for intractable cancer pain associated with pelvic floor lesions: a retrospective analysis of 36 cases.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Opioid Use in Cancer Pain Management: Navigating the Line Between Relief and Addiction.International journal of molecular sciences · 2025Review
- Memory function in patients with opioid dependence treated with buprenorphine and methadone in comparison with healthy persons.Scientific reports · 2025Article
- Methadone in the madness: a case series and review of methadone management in hospital settings.Pain management · 2025Review
- Opioid metabolism and drug-drug interaction in cancer.The oncologist · 2024Review
- Dietary Influence on Drug Efficacy: A Comprehensive Review of Ketogenic Diet-Pharmacotherapy Interactions.Nutrients · 2024Review
- The Use of Low-Dose Methadone as Add-On to Ongoing Opioid Treatment in Palliative Cancer Care-An Underrated Treatment?Life (Basel, Switzerland) · 2022Review
- First-line methadone for cancer pain: titration time analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- How to Use Methadone in an Era of an Opioid Epidemic.Current treatment options in oncology · 2020Review
- Comprehensive Perioperative Management Considerations in Patients Taking Methadone.Current pain and headache reports · 2019Review
- Methadone in Cancer Pain.Indian journal of palliative careArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methadone is a naturally long-acting analgesic with unique pharmacodynamic and pharmacokinetic properties compared to other opioids, available now in India, to treat severe pain. It has the potential to dramatically relieve suffering among patients with serious illness who are living with persistent physical pain. However, clinicians must appreciate its unique pharmacologic properties and its use in clinical practice safely and effectively. The available formulation in India is a racemic mixture of the S- and R-enantiomers, and as such, it will have a propensity for drug-drug and drug-genetic interactions that can increase the risk of Torsades de Point and respiratory depression. Appropriate patient selection, careful dosing and thorough monitoring of methadone will mitigate these risks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.