Evidence map›Paper›PMID 29497192›Full record

ArticleIndian journal of psychiatry

No genetic association between A118G polymorphism of μ-opioid receptor gene and schizophrenia and bipolar disorders.

Shaghayegh Yazdani, Vahid Salimi, Mohammad Reza Eshraghian, Mohammad Shayestehpour, Alireza Pourtalebi-Firoozabadi, Bizhan Romani, Azadeh Shadab, Mohammad Reza Aghasadeghi, Jila Yavarian

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Article in Indian journal of psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Shaghayegh YazdaniDepartment of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Vahid SalimiDepartment of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Reza EshraghianDepartment of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad ShayestehpourDepartment of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Alireza Pourtalebi-FiroozabadiGenomic Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Bizhan RomaniDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
Azadeh ShadabDepartment of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Reza AghasadeghiDepartment of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran.
Jila YavarianDepartment of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Tehran University of Medical Sciences · IRBirjand University of Medical Sciences · IRPasteur Institute of Iran · IRUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSchizophrenia (SZ) and bipolar disorder (BD) are chronic and multifactorial psychiatric disorders that might be affected by different genes in combination with environmental factors. There is evidence of association between polymorphisms of μ-opioid receptor gene (OPRM1) with these disorders.

objectivesThe aim of this study was to investigate the genetic association between OPRM1 A118G SNP in SZ and BD patients in comparison with healthy controls (HCs). MATERIALS AND

methodsOne single-nucleotide polymorphism in OPRM1 was genotyped using TaqMan real-time PCR assay in 203 SZ and BD patients and 389 HCs.

resultsThere was no statistically significant difference in genotypic and allelic frequencies of OPRM1 A118G SNP between HCs and SZ/BD patients.

conclusionsTo find the underlying genetic factors associated with these complex disorders, further studies need to be conducted using larger sample size, different genetic populations, and different gene variations.

Indexed as

bipolar disorderschizophreniasingle-nucleotide polymorphismμ-opioid receptor gene

Identifiers

PMID29497192
PMCPMC5806329
OpenAlexW2767200505

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.