ArticleSpinal cord2018
In cervical spondylotic myelopathy spinal cord motion is focally increased at the level of stenosis: a controlled cross-sectional study.
Article in Spinal cord, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- CSF Flow and Spinal Cord Motion in Patients With Spontaneous Intracranial Hypotension: A Phase Contrast MRI Study.Neurology · 2023Trial
- T2-weighted MRI high signal in cervical spondylotic myelopathy is associated with dynamic change.Journal of orthopaedic surgery and research · 2025Article
- Finite element modeling and analysis of effect of preexisting cervical degenerative disease on the spinal cord during flexion and extension.Medical & biological engineering & computing · 2024Article
- Potential thresholds of critically increased cardiac-related spinal cord motion in degenerative cervical myelopathy.Frontiers in neurology · 2024Article
- Increased cranio-caudal spinal cord oscillations are the cardinal pathophysiological change in degenerative cervical myelopathy.Frontiers in neurology · 2023Article
- Could spinal cord oscillation contribute to spinal cord injury in degenerative cervical myelopathy?Brain & spine · 2023Article
- Comparison of axial and sagittal spinal cord motion measurements in degenerative cervical myelopathy.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- A New Framework for Investigating the Biological Basis of Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 5]: Mechanical Stress, Vulnerability and Time.Global spine journal · 2022Article
- Spinal Cord Motion in Degenerative Cervical Myelopathy: The Level of the Stenotic Segment and Gender Cause Altered Pathodynamics.Journal of clinical medicine · 2021Article
- The Restless Spinal Cord in Degenerative Cervical Myelopathy.AJNR. American journal of neuroradiology · 2021Article
- The Dancing Cord: Inherent Spinal Cord Motion and Its Effect on Cord Dose in Spine Stereotactic Body Radiation Therapy.Neurosurgery · 2020Article
- Article
- Degenerative cervical myelopathy - update and future directions.Nature reviews. Neurology · 2020Review
- Assessment of spinal cord motion as a new diagnostic MRI-parameter in cervical spinal canal stenosis: study protocol on a prospective longitudinal trial.Journal of orthopaedic surgery and research · 2019Article
- Segmental differences of cervical spinal cord motion: advancing from confounders to a diagnostic tool.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designLevel-, age-, and gender-matched controlled cross-sectional cohort study.
objectivesTo investigate alterations of spinal cord (SC) motion within cervical spondylotic myelopathy (CSM) across the cervical spinal segments and its relation to cerebrospinal fluid (CSF)-flow, anatomic conditions, and clinical parameters.
settingUniversity Hospital Balgrist, Zurich, Switzerland.
methodsOverall, 12 patients suffering from CSM at level C5 and 12 controls underwent cardiac-gated 2D phase-contrast-MRI at level C2 and C5 and standard MRI sequences. Parameters of interest: Velocity measurements of SC and CSF (area under the curve = total displacement (normalization for duration of the heart cycle), total displacement ratio (C5/C2; intraindividual normalization for confounders)), spinal canal diameters, clinical motor- and sensory scores, and performance measures.
resultsInterrater reliability was excellent for SC motion at both levels and for CSF flow at C2, but not reliable for CSF flow at C5. Within controls, SC motion at C2 positively correlated with SC motion at C5 (p = 0.000); this correlation diminished in patients (p = 0.860). SC total displacement ratio was significantly increased in patients (p = 0.029) and correlated with clinical impairment (p = 0.017). Morphometric measures of the extent of stenosis were not related to SC motion or clinical symptoms.
conclusionThe findings revealed physiological interactions of CSF flow and SC motion across the cervical spine in healthy controls while being diminished in CSM patients. Findings of focally increased SC motion at the level of stenosis were related to clinical impairment and might be promising as a diagnostic and prognostic marker in CSM. SPONSORSHIP: CRPP Neurorehab of the University of Zurich, Switzerland.
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