ArticleExperimental & molecular medicine2018
Sleep deprivation disrupts the lacrimal system and induces dry eye disease.
Article in Experimental & molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 124 citations in OpenAlex.
- Association between circadian rhythm sleep disorders and dry eye disease: a retrospective cohort study.Scientific reports · 2026Article
- Hormone therapy preserves ocular surface integrity following circadian alignment disturbance in menopausal rats.BMC ophthalmology · 2026Article
- Activation of PPARγ Attenuates Age-Related Lacrimal Gland Dysfunction by Alleviating Endoplasmic Reticulum Stress-Mediated Ferroptosis.Investigative ophthalmology & visual science · 2026Article
- Sleep deprivation drives hepatic steatosis via sympathetic sprouting-induced ER stress in young male mice.JHEP reports : innovation in hepatology · 2026Article
- Sleep deprivation disrupts lacrimal gland homeostasis via hypothalamic-pituitary-adrenal axis and gut dysbiosis in mice.Communications biology · 2026Article
- β-Adrenergic Signaling Contributes to Circadian and Lipid Dysregulation in Meibomian Glands During Chronic Psychological Stress.Investigative ophthalmology & visual science · 2026Article
- Correlation of ocular surface function with sleep quality, anxiety, and depression in patients with dry eye disease.World journal of psychiatry · 2026Article
- Focus on sex hormone axis disorder: exploring the susceptibility mechanism of dry eye in perimenopausal women.Frontiers in medicine · 2026Review
- Epidemiological study of dry eye disease in Gansu Province based on mathematical modeling: analysis of regional population characteristics and identification of risk factors.Frontiers in public health · 2026Article
- Development and validation of a risk prediction model for dry eye disease in myopic children.Frontiers in medicine · 2026Article
- Chronic Restraint Stress Misaligns Corneal Clock via β-Adrenergic and Glucocorticoid Signaling, Altering Epithelial, Neural, Immune, Metabolic States.Investigative ophthalmology & visual science · 2025Article
- Epidemiological Study of Functional Dry Eye Disease in Working-class Population in Shanghai, China.La Medicina del lavoro · 2025Article
- Circadian disruption and ROS-NLRP3 signaling mediate sleep deprivation-enhanced silica nanoparticle toxicity in lacrimal glands.Journal of nanobiotechnology · 2025Article
- Electronic device exposure and dry eye symptoms among medical and nonmedical Palestinian university students: a multicenter cross-sectional study of associated factors.BMC ophthalmology · 2025Article
- Prevalence of dry eye disease and its association with sleep quality and depression: a hospital-based survey in Thai population.BMJ open · 2025Article
- Decades of Night-Shift Work Induce Diurnal Disruption and Corneal Adaptations: Evidence from Pentacam Analysis.International journal of environmental research and public health · 2025Article
- Sleep deprivation and corneal chronobiology: reevaluating overnight corneal changes.Scientific reports · 2025Article
- Circadian clocks and their role in kidney and eye diseases across organ systems.Frontiers in physiology · 2025Review
- Analysis of Sleep Quality Evaluation Factors Affecting Dry Eye Syndrome.International journal of general medicine · 2025Article
- Multifaceted mitochondrial as a novel therapeutic target in dry eye: insights and interventions.Cell death discovery · 2024Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep deficiency is a common public health problem associated with many diseases, such as obesity and cardiovascular disease. In this study, we established a sleep deprivation (SD) mouse model using a 'stick over water' method and observed the effect of sleep deficiency on ocular surface health. We found that SD decreased aqueous tear secretion; increased corneal epithelial cell defects, corneal sensitivity, and apoptosis; and induced squamous metaplasia of the corneal epithelium. These pathological changes mimic the typical features of dry eye. However, there was no obvious corneal inflammation and conjunctival goblet cell change after SD for 10 days. Meanwhile, lacrimal gland hypertrophy along with abnormal lipid metabolites, secretory proteins and free amino-acid profiles became apparent as the SD duration increased. Furthermore, the ocular surface changes induced by SD for 10 days were largely reversed after 14 days of rest. We conclude that SD compromises lacrimal system function and induces dry eye. These findings will benefit the clinical diagnosis and treatment of sleep-disorder-related ocular surface diseases.
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Registered trials
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