ReviewExperimental & molecular medicine2018
Whither systems medicine?
Review in Experimental & molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Advancing Patient-Centred AI With Adaptive Machine Learning.Cancer medicine · 2026Review
- The Integrated Human System Framework: A Conceptual Model of Skin as a Biological Interface Across Health and Well-Being.Clinical, cosmetic and investigational dermatology · 2026Review
- Interdisciplinary Research in Iran VII: The Convergence of Biology and Artificial Intelligence.Journal of medical signals and sensors · 2025Article
- A biological sequence comparison algorithm using quantum computers.Scientific reports · 2023Article
- What's next for computational systems biology?Frontiers in systems biology · 2023Review
- Leveraging transcriptomics for precision diagnosis: Lessons learned from cancer and sepsis.Frontiers in genetics · 2023Review
- Disease-Gene Networks of Skin Pigmentation Disorders and Reconstruction of Protein-Protein Interaction Networks.Bioengineering (Basel, Switzerland) · 2022Article
- Assessment of Biobanking Knowledge and Attitudes towards Biospecimen Donation among Healthcare Providers in Saudi Arabia.International journal of environmental research and public health · 2022Article
- Oxidative Stress in Type 2 Diabetes: The Case for Future Pediatric Redoxomics Studies.Antioxidants (Basel, Switzerland) · 2022Review
- Innovations in Genomics and Big Data Analytics for Personalized Medicine and Health Care: A Review.International journal of molecular sciences · 2022Review
- Computational Models for Clinical Applications in Personalized Medicine-Guidelines and Recommendations for Data Integration and Model Validation.Journal of personalized medicine · 2022Review
- Personalized Medicine to Improve Treatment of Dopa-Responsive Dystonia-A Focus on Tyrosine Hydroxylase Deficiency.Journal of personalized medicine · 2021Review
- A Vision of Future Healthcare: Potential Opportunities and Risks of Systems Medicine from a Citizen and Patient Perspective-Results of a Qualitative Study.International journal of environmental research and public health · 2021Article
- Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility.CPT: pharmacometrics & systems pharmacology · 2021Article
- Deep learning in systems medicine.Briefings in bioinformatics · 2021Review
- Mathematical Modelling in Biomedicine: A Primer for the Curious and the Skeptic.International journal of molecular sciences · 2021Review
- How aging of the global population is changing oncology.Ecancermedicalscience · 2021Article
- Are all models wrong?Computational and systems oncology · 2020Article
- Strategies for Testing Intervention Matching Schemes in Cancer.Clinical pharmacology and therapeutics · 2020Review
- Towards standardization guidelines for in silico approaches in personalized medicine.Journal of integrative bioinformatics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New technologies to generate, store and retrieve medical and research data are inducing a rapid change in clinical and translational research and health care. Systems medicine is the interdisciplinary approach wherein physicians and clinical investigators team up with experts from biology, biostatistics, informatics, mathematics and computational modeling to develop methods to use new and stored data to the benefit of the patient. We here provide a critical assessment of the opportunities and challenges arising out of systems approaches in medicine and from this provide a definition of what systems medicine entails. Based on our analysis of current developments in medicine and healthcare and associated research needs, we emphasize the role of systems medicine as a multilevel and multidisciplinary methodological framework for informed data acquisition and interdisciplinary data analysis to extract previously inaccessible knowledge for the benefit of patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.