Evidence map›Paper›PMID 29497165›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018

mTORC2 in the dorsomedial striatum of mice contributes to alcohol-dependent F-Actin polymerization, structural modifications, and consumption.

Sophie Laguesse, Nadege Morisot, Khanhky Phamluong, Samuel A Sakhai, Dorit Ron

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
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  6. Article
  7. Alcohol and the brain: from genes to circuits.Trends in neurosciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sophie LaguesseDepartment of Neurology, University of California, San Francisco, San Francisco, CA, 94143, USA.
Nadege MorisotDepartment of Neurology, University of California, San Francisco, San Francisco, CA, 94143, USA.
Khanhky PhamluongDepartment of Neurology, University of California, San Francisco, San Francisco, CA, 94143, USA.
Samuel A SakhaiDepartment of Neurology, University of California, San Francisco, San Francisco, CA, 94143, USA.
Dorit RonDepartment of Neurology, University of California, San Francisco, San Francisco, CA, 94143, USA. dorit.ron@ucsf.edu.
University of California, San Francisco · US

Funding

Vector, Transgenic, and Imaging CoreP50AA017072 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RON, DORIT · 2008 to 2017
$13.9M
NIAAA NIH HHS P50 AA017072
6 · The paper itself

Abstract

Actin is highly enriched at dendritic spines, and actin remodeling plays an essential role in structural plasticity. The mammalian target of rapamycin complex 2 (mTORC2) is a regulator of actin polymerization. Here, we report that alcohol consumption increases F-actin content in the dorsomedial striatum (DMS) of mice, thereby altering dendritic spine morphology in a mechanism that requires mTORC2. Specifically, we found that excessive alcohol consumption increases mTORC2 activity in the DMS, and that knockdown of Rictor, an essential component of mTORC2 signaling, reduces actin polymerization, and attenuates the alcohol-dependent alterations in spine head size and the number of mushroom spines. Finally, we show that knockdown of Rictor in the DMS reduces alcohol consumption, whereas intra-DMS infusion of the mTORC2 activator, A-443654, increases alcohol intake. Together, these results suggest that mTORC2 in the DMS facilitates the formation of F-actin, which in turn induces changes in spine structure to promote and/or maintain excessive alcohol intake.

Indexed as

ActinsAlcohol DrinkingAnimalsCorpus StriatumDendritic SpinesEthanolGene Knockdown TechniquesIndazolesIndolesMechanistic Target of Rapamycin Complex 2MicePolymerizationRapamycin-Insensitive Companion of mTOR ProteinA 443654ActinsEthanolIndazolesIndolesMechanistic Target of Rapamycin Complex 2Rapamycin-Insensitive Companion of mTOR Proteinrictor protein, mouse

Identifiers

PMID29497165
PMCPMC5983552
OpenAlexW2791472250

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.