ArticleScientific reports2018
Antimicrobial mechanisms due to hyperpolarisation induced by nanoporous Au.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
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- Potential role of metal nanoparticles in treatment of peri-implant mucositis and peri-implantitis.Biomedical engineering online · 2024Review
- Chemically diverse antimicrobial peptides induce hyperpolarization of the E. coli membrane.Communications biology · 2024Article
- Vapor-Phase-Deposited Ag/Ir and Ag/Au Film Heterostructures for Implant Materials: Cytotoxic, Antibacterial and Histological Studies.International journal of molecular sciences · 2024Article
- Research and Application of Chitosan Nanoparticles in Orthopedic Infections.International journal of nanomedicine · 2024Review
- Unusual effects of a nanoporous gold substrate on cell adhesion and differentiation because of independent multi-branch signaling of focal adhesions.Journal of materials science. Materials in medicine · 2023Article
- Five nanometer size highly positive silver nanoparticles are bactericidal targeting cell wall and adherent fimbriae expression.Scientific reports · 2022Article
- Rationally designed foldameric adjuvants enhance antibiotic efficacyMolecular systems design & engineering · 2022Article
- Why have nanotechnologies been underutilized in the global uprising against the coronavirus pandemic?Nanomedicine (London, England) · 2020Review
- Electronic origin of antimicrobial activity owing to surface effect.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanomaterials such as nanoparticles exhibit remarkable antimicrobial activities. Nanoparticles directly disturb the cell membrane or cytoplasmic proteins because they pass through the cell wall. Nanoporous Au (NPG) is another antimicrobial nanomaterial, which cannot pass through the cell wall of bacteria but can still kill bacteria, utilising interactions between the surface of NPG and cell wall of bacteria. The origins of antimicrobial activities without direct interactions are unknown. It is necessary to elucidate these mechanisms to ensure safe usage. Here we show that the antimicrobial mechanism of NPG consists of two interactions: between the surface of NPG and cell wall, and between the cell wall and cell membrane. Fluorescent experiments showed that the cell wall was negatively hyperpolarised by NPG, and molecular dynamics simulations and first-principles calculations suggested that the hyperpolarisation of the cell wall leads to delicate structural changes in the membrane proteins, rendering them bactericidal. Thus, the hyperpolarisation induced by NPG plays a critical role in both interactions. The combination of molecular dynamics simulations and first-principles calculations allows a deeper understanding of the interactions between metallic surfaces and biomolecules, because charge transfer and exchange interactions are calculated exactly.
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Registered trials
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