Evidence map›Paper›PMID 29497127›Full record

ArticleScientific reports2018

Genetic variants in two pathways influence serum urate levels and gout risk: a systematic pathway analysis.

Zheng Dong, Jingru Zhou, Xia Xu, Shuai Jiang, Yuan Li, Dongbao Zhao, Chengde Yang, Yanyun Ma, Yi Wang, Hongjun He and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 1 country.

Zheng DongState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University Jiangwan Campus, Shanghai, China.
Jingru ZhouState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University Jiangwan Campus, Shanghai, China.
Xia XuDivision of Rheumatology and Immunology, Changhai Hospital, Shanghai, China.
Shuai JiangState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University Jiangwan Campus, Shanghai, China.
Yuan LiState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University Jiangwan Campus, Shanghai, China.
Dongbao ZhaoDivision of Rheumatology and Immunology, Changhai Hospital, Shanghai, China.
Chengde YangDivision of Rheumatology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yanyun MaMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.
Yi WangMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.
Hongjun HeDivision of Rheumatology, Taixing People's Hospital, Jiangsu Province, China.
Hengdong JiDivision of Rheumatology, Taizhou People's Hospital, Jiangsu Province, China.
Juan ZhangFudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu Province, China.
Ziyu YuanFudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu Province, China.
Yajun YangState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University Jiangwan Campus, Shanghai, China.
Xiaofeng WangState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University Jiangwan Campus, Shanghai, China.
Yafei PangDivision of Rheumatology and Immunology, Changhai Hospital, Shanghai, China.
Li JinState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University Jiangwan Campus, Shanghai, China.
Hejian ZouDivision of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China.
Jiucun WangState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University Jiangwan Campus, Shanghai, China. jcwang@fudan.edu.cn.
Fudan University · CNSecond Military Medical University · CNHuashan Hospital · CNNantong University · CNRuijin Hospital · CNState Key Laboratory of Genetic EngineeringTaixing People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aims of this study were to identify candidate pathways associated with serum urate and to explore the genetic effect of those pathways on the risk of gout. Pathway analysis of the loci identified in genome-wide association studies (GWASs) showed that the ion transmembrane transporter activity pathway (GO: 0015075) and the secondary active transmembrane transporter activity pathway (GO: 0015291) were both associated with serum urate concentrations, with P

Indexed as

Asian PeopleCase-Control StudiesChinaFemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeGoutHumansHyperuricemiaIon TransportMalePolymorphism, Single NucleotideRisk FactorsSodium-Phosphate Cotransporter Proteins, Type ISLC17A2 protein, humanSodium-Phosphate Cotransporter Proteins, Type IUric Acid

Identifiers

PMID29497127
PMCPMC5832812
OpenAlexW2805563591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.