Evidence map›Paper›PMID 29497109›Full record

ArticleScientific reports2018

Melanopsin photoreception contributes to human visual detection, temporal and colour processing.

Andrew J Zele, Beatrix Feigl, Prakash Adhikari, Michelle L Maynard, Dingcai Cao

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 118 citations in OpenAlex.

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  11. What can the eye see with melanopsin?Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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  17. Melanopsin enhances image persistence.Current biology : CB · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Andrew J ZeleInstitute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia. andrew.zele@qut.edu.au.ORCID 0000-0003-0291-9929
Beatrix FeiglInstitute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia.
Prakash AdhikariInstitute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia.
Michelle L MaynardInstitute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia.
Dingcai CaoDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, USA.
Queensland University of Technology · AUUniversity of Illinois Chicago · US

Funding

Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCANANY, JAMES JASON · 1985 to 2025
$14.8M
The Effect of Alcohol on Retinal Photic Signaling to the Human Circadian SystemR01AA023839 · NIAAA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CAO, DINGCAI · 2016 to 2019
$1.6M
NEI NIH HHS P30 EY001792NIAAA NIH HHS R01 AA023839
6 · The paper itself

Abstract

The visual consequences of melanopsin photoreception in humans are not well understood. Here we studied melanopsin photoreception using a technique of photoreceptor silent substitution with five calibrated spectral lights after minimising the effects of individual differences in optical pre-receptoral filtering and desensitising penumbral cones in the shadow of retinal blood vessels. We demonstrate that putative melanopsin-mediated image-forming vision corresponds to an opponent S-OFF L + M-ON response property, with an average temporal resolution up to approximately 5 Hz, and >10x higher thresholds than red-green colour vision. With a capacity for signalling colour and integrating slowly changing lights, melanopsin-expressing intrinsically photosensitive retinal ganglion cells maybe the fifth photoreceptor type for peripheral vision.

Indexed as

AdultColorColor VisionFemaleHumansLightMaleMelanopsinPhotic StimulationPhotoreceptor CellsRetinaRetinal Cone Photoreceptor CellsRetinal Ganglion CellsRetinal Rod Photoreceptor CellsRod OpsinsVision, OcularMelanopsinRod Opsins

Identifiers

PMID29497109
PMCPMC5832793
OpenAlexW2790606801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.