Evidence map›Paper›PMID 29497057›Full record

ArticleNature communications2018

Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection.

Meirong Bai, Roman Vozdek, Aleš Hnízda, Chenxiao Jiang, Bingying Wang, Ladislav Kuchar, Tiejun Li, Yuefan Zhang, Chase Wood, Liang Feng and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. The neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Dual role of neuroplastin in pancreatic β cells: Regulating insulin secretion and promoting islet inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Article
  13. Article
  14. Anti-Aging Effect ofInternational journal of molecular sciences · 2024
    Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Meirong BaiCardiovascular Research Institute and Department of Physiology, University of California San Francisco, San Francisco, CA, 94158, USA.
Roman VozdekCardiovascular Research Institute and Department of Physiology, University of California San Francisco, San Francisco, CA, 94158, USA.
Aleš HnízdaInstitute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10, Prague 6, Czech Republic.
Chenxiao JiangKey Laboratory of Molecular Medicine, Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Bingying WangCardiovascular Research Institute and Department of Physiology, University of California San Francisco, San Francisco, CA, 94158, USA.
Ladislav KucharResearch Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, 12808, Czech Republic.
Tiejun LiDepartment of Pharmacology, Second Military Medical University, Shanghai, 200433, China.
Yuefan ZhangDepartment of Pharmacology, Second Military Medical University, Shanghai, 200433, China.
Chase WoodDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA, 94305, USA.
Liang FengDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA, 94305, USA.
Yongjun DangKey Laboratory of Molecular Medicine, Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Dengke K MaCardiovascular Research Institute and Department of Physiology, University of California San Francisco, San Francisco, CA, 94158, USA. Dengke.Ma@ucsf.edu.ORCID http://orcid.org/0000-0002-5619-7485
University of California, San Francisco · USSecond Military Medical University · CNShanghai Medical College of Fudan University · CNStanford University · USCharles University · CZCzech Academy of Sciences, Institute of Organic Chemistry and Biochemistry · CZ

Funding

Dissecting a Novel Genetic Pathway for Fatty Acid Desaturation and Temperature AdaptationR01GM117461 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MA, DENGKE · 2016 to 2020
$1.6M
Control of Anoxia-Reoxygenation Responses by the O2-sensing Enzyme EGL-9 PathwayR00HL116654 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MA, DENGKE · 2015 to 2017
$744k
NHLBI NIH HHS R00 HL116654NIGMS NIH HHS R01 GM117461
6 · The paper itself

Abstract

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER) protein that can be secreted and protects dopamine neurons and cardiomyocytes from ER stress and apoptosis. The mechanism of action of extracellular MANF has long been elusive. From a genetic screen for mutants with abnormal ER stress response, we identified the gene Y54G2A.23 as the evolutionarily conserved C. elegans MANF orthologue. We find that MANF binds to the lipid sulfatide, also known as 3-O-sulfogalactosylceramide present in serum and outer-cell membrane leaflets, directly in isolated forms and in reconstituted lipid micelles. Sulfatide binding promotes cellular MANF uptake and cytoprotection from hypoxia-induced cell death. Heightened ER stress responses of MANF-null C. elegans mutants and mammalian cells are alleviated by human MANF in a sulfatide-dependent manner. Our results demonstrate conserved roles of MANF in sulfatide binding and ER stress response, supporting sulfatide as a long-sought lipid mediator of MANF's cytoprotection.

Indexed as

CytoprotectionEndoplasmic Reticulum StressAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsHEK293 CellsHumansLipid MetabolismNerve Growth FactorsSulfoglycosphingolipidsCaenorhabditis elegans Proteinsmanf-1 protein, C elegansMANF protein, humanNerve Growth FactorsSulfoglycosphingolipids

Identifiers

PMID29497057
PMCPMC5832864
OpenAlexW2953074759

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.