Evidence map›Paper›PMID 29497038›Full record

ArticleCell death & disease2018

The distinct roles of mesenchymal stem cells in the initial and progressive stage of hepatocarcinoma.

Chen Zong, Hangjie Zhang, Xue Yang, Lu Gao, Jing Hou, Fei Ye, Jinghua Jiang, Yang Yang, Rong Li, Zhipeng Han and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 46 citations in OpenAlex.

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  5. Frontiers in cell and developmental biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Chen ZongTumor Immunology and Gene Therapy Center, Third Affiliated Hospital of Second Military Medical University, 200438, Shanghai, China.
Hangjie ZhangTumor Immunology and Gene Therapy Center, Third Affiliated Hospital of Second Military Medical University, 200438, Shanghai, China.
Xue YangTumor Immunology and Gene Therapy Center, Third Affiliated Hospital of Second Military Medical University, 200438, Shanghai, China.
Lu GaoTumor Immunology and Gene Therapy Center, Third Affiliated Hospital of Second Military Medical University, 200438, Shanghai, China.
Jing HouDepartment of Pharmacy, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Fei YeTumor Immunology and Gene Therapy Center, Third Affiliated Hospital of Second Military Medical University, 200438, Shanghai, China.
Jinghua JiangTumor Immunology and Gene Therapy Center, Third Affiliated Hospital of Second Military Medical University, 200438, Shanghai, China.
Yang YangTumor Immunology and Gene Therapy Center, Third Affiliated Hospital of Second Military Medical University, 200438, Shanghai, China.
Rong LiTumor Immunology and Gene Therapy Center, Third Affiliated Hospital of Second Military Medical University, 200438, Shanghai, China.
Zhipeng HanTumor Immunology and Gene Therapy Center, Third Affiliated Hospital of Second Military Medical University, 200438, Shanghai, China. hanzhipeng0311@126.com.
Lixin WeiTumor Immunology and Gene Therapy Center, Third Affiliated Hospital of Second Military Medical University, 200438, Shanghai, China. weilixin_smmu@163.com.
Second Military Medical University · CNChanghai Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidences suggest that mesenchymal stem cells (MSCs) could migrate to the tumor site and play a vital role in tumorigenesis and progression. However, it is still a lively debate whether MSCs exert a pro- or anticancer action. Cancer development and progression is a multistep process. Therefore, we investigated the effect of MSCs on hepatocarcinoma and whether the role of MSCs depends on the stage of cancer development. In our study, chronically exposing rats to N-diethylnitrosamine (DEN) was employed as hepatocarcinoma model. And to evaluate the effect of MSCs on hepatocarcinoma, the animals were divided into three groups: rats were injected with MSCs in the initial (DEN + MSC (Is) group) or progressive stage (DEN + MSC (Ps) group) of hepatocarcinoma, respectively. Rats injected with PBS were used as control (DEN group). Interestingly, we found that MSCs had a tumor-suppressive effect in the Is of hepatocarcinoma, yet a tumor-promotive effect in the Ps. In the Is, MSCs showed a protective role against drug damage, possibly through reducing DNA damage and ROS accumulation. Meanwhile, MSCs in the Is also exhibited anti-inflammatory and anti-liver fibrosis effect. Further, in the Ps, MSCs facilitated tumor formation not only by enhancing cancer cell proliferation but also through promoting stem cell-like properties and epithelial-mesenchymal transition of liver cancer cells. Taken together, MSCs have a paradoxical role in the different stages of hepatocarcinogenesis, which sheds new light on the role of MSCs in hepatocarcinoma and cautions the therapeutic application of MSCs for liver cancer.

Indexed as

AnimalsCarcinoma, HepatocellularCell MovementCell ProliferationDisease ProgressionEpithelial-Mesenchymal TransitionFemaleHumansLiver NeoplasmsMaleMesenchymal Stem CellsNeoplasm StagingRatsRats, Sprague-DawleyReactive Oxygen SpeciesReactive Oxygen Species

Identifiers

PMID29497038
PMCPMC5832809
OpenAlexW2794099615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.