Evidence map›Paper›PMID 29496991›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2018

Noninvasive Imaging of Drug-Induced Liver Injury with

Jessica R Salas, Bao Ying Chen, Alicia Wong, Sergio Duarte, Stephanie A K Angarita, Gerald S Lipshutz, Owen N Witte, Peter M Clark

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Recent developments in translational imaging of in vivo gene therapy outcomes.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020
    Article
  7. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jessica R SalasDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles California.
Bao Ying ChenDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles California.
Alicia WongDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles California.
Sergio DuarteDepartment of Surgery, University of California, Los Angeles California.
Stephanie A K AngaritaDepartment of Surgery, University of California, Los Angeles California.
Gerald S LipshutzDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles California.
Owen N WitteDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles California.
Peter M ClarkDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles California pclark@mednet.ucla.edu.
University of California, Los Angeles · USInstitute for Molecular Medicine · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Cell and Gene Replacement Strategies for Arginase DeficiencyR01NS100979 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIPSHUTZ, GERALD S · 2017 to 2021
$1.7M
NCATS NIH HHS UL1 TR000124NCI NIH HHS P30 CA016042NINDS NIH HHS R01 NS100979
6 · The paper itself

Abstract

Drug-induced liver failure is a significant indication for a liver transplant, and unexpected liver toxicity is a major reason that otherwise effective therapies are removed from the market. Various methods exist for monitoring liver injury but are often inadequate to predict liver failure. New diagnostic tools are needed.

Indexed as

Positron Emission Tomography Computed TomographyAcetaminophenAnimalsArabinoseCell LineChemical and Drug Induced Liver InjuryDose-Response Relationship, DrugHumansLiverMiceMice, Inbred C57BLSurvival AnalysisTime Factors2'-deoxy-2'-fluoroarabinoseAcetaminophenArabinosedrug-induced liver failurehepatocytesPET imaging

Identifiers

PMID29496991
PMCPMC6071498
OpenAlexW2792499922

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.