Evidence map›Paper›PMID 29496987›Full record

Trial reportJournal of nuclear medicine : official publication, Society of Nuclear Medicine2018

Jennifer M Coughlin, Stephanie Slania, Yong Du, Hailey B Rosenthal, Wojciech G Lesniak, Il Minn, Gwenn S Smith, Robert F Dannals, Hiroto Kuwabara, Dean F Wong and 3 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Reduction in [Brain research · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Bidirectional Associations among Nicotine and Tobacco Smoke, NeuroHIV, and Antiretroviral Therapy.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  8. Current radiotracers to image neurodegenerative diseases.EJNMMI radiopharmacy and chemistry · 2019
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jennifer M CoughlinDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Stephanie SlaniaDepartment of Biomedical Engineering, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Yong DuRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Hailey B RosenthalRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Wojciech G LesniakRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Il MinnRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Gwenn S SmithDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Robert F DannalsRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Hiroto KuwabaraRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Dean F WongDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Yuchuan WangRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Andrew G HortiRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Martin G PomperDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland mpomper@jhmi.edu.

Funding

Longitudinal Molecular Imaging of Neuropathology and Serotonin in Mild Cognitive ImpairmentR01AG059390 · NIA · JOHNS HOPKINS UNIVERSITY · PI SMITH, GWENN S · 2018 to 2022
$4.8M
Extrathalamic nAChR-PET for Imaging NeurodegenerationR33AG037298 · NIA · JOHNS HOPKINS UNIVERSITY · PI HORTI, ANDREW G, POMPER, MARTIN G · 2012 to 2014
$1.2M
DEDICATED HIGH PERFORM HUMAB BRAIN/PRECLIN PET: SUBSTANCE ABUSE: ALCOHOL, COCAINS10RR017219 · NCRR · JOHNS HOPKINS UNIVERSITY · PI WONG, DEAN FOSTER · 2004 to 2004
$500k
NCRR NIH HHS S10 RR017219NIA NIH HHS R01 AG059390NIA NIH HHS R33 AG037298
6 · The paper itself

Abstract

Reduced density of the α4β2 nicotinic acetylcholine receptor (α4β2-nAChR) in the cortex and hippocampus of the human brain has been reported in aging and patients with neurodegenerative disease. This study assessed the pharmacokinetic behavior of

Indexed as

Positron-Emission TomographyAdultAgedAged, 80 and overAgingBrainCognitionFemaleHippocampusHumansMaleMiddle AgedReceptors, Nicotinicnicotinic receptor alpha4beta2Receptors, Nicotinic18F-XTRAhealthy agingnicotinic acetylcholine receptorPET imaging

Identifiers

PMID29496987
PMCPMC6167533

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.