ArticleScience (New York, N.Y.)2018
Quantitative analysis of population-scale family trees with millions of relatives.
Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
102 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Multivariate genomic scan implicates novel loci and haem metabolism in human ageing.Nature communications · 2020Pooled it
- A Prospective Analysis of Genetic Variants Associated with Human Lifespan.G3 (Bethesda, Md.) · 2019Pooled it
- A meta-analysis of genome-wide association studies identifies multiple longevity genes.Nature communications · 2019Pooled it
- Tracing the Right Path: Determination of Large Pedigree Segmentation and Relatedness.Behavior genetics · 2026Article
- Review
- Artificial intelligence enables scale, consistency, and rigor in forensic identity inference.Croatian medical journal · 2026Review
- Unravelling the genetic architecture of cerebral small vessel disease in the context of stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Article
- Multigenerational and gender-symmetric transmission of migration behaviors in historical Quebec.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Analysing Biases in Genealogies Using Demographic Microsimulation.European journal of population = Revue europeenne de demographie · 2025Article
- Contributions of inherited mtDNA to longevity: evidence from extended pedigrees with 176 million kinship pairs.EBioMedicine · 2025Article
- The association of a polygenic lifespan score with the risk of common age-related diseases and mortality.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Analysis of lifespan across diversity outbred mouse studies identifies multiple longevity-associated loci.Genetics · 2025Article
- Detecting mtDNA Effects with an Extended Pedigree Model: An Analysis of Statistical Power and Estimation Bias.Behavior genetics · 2025Article
- py_ped_sim: a flexible forward pedigree and genetic simulator for complex family pedigree analysis.BMC bioinformatics · 2025Article
- Dynamic changes in gene expression through aging in Drosophila melanogaster heads.G3 (Bethesda, Md.) · 2025Article
- Integrating the environmental and genetic architectures of aging and mortality.Nature medicine · 2025Article
- A likelihood ratio framework for inferring close kinship from dynamically selected SNPs.Frontiers in genetics · 2025Article
- Geroscience in heart failure: the search for therapeutic targets in the shared pathobiology of human aging and heart failure.The journal of cardiovascular aging · 2025Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Family trees have vast applications in fields as diverse as genetics, anthropology, and economics. However, the collection of extended family trees is tedious and usually relies on resources with limited geographical scope and complex data usage restrictions. We collected 86 million profiles from publicly available online data shared by genealogy enthusiasts. After extensive cleaning and validation, we obtained population-scale family trees, including a single pedigree of 13 million individuals. We leveraged the data to partition the genetic architecture of human longevity and to provide insights into the geographical dispersion of families. We also report a simple digital procedure to overlay other data sets with our resource.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.