ArticleAJNR. American journal of neuroradiology2018
Altered Regional Homogeneity in Chronic Insomnia Disorder with or without Cognitive Impairment.
Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Efficacy of repetitive transcranial magnetic stimulation for insomnia disorder: a systematic review and meta-analysis of randomized controlled trials.Frontiers in neuroscience · 2026Pooled it
- Comparison of resting-state brain activity between insomnia and generalized anxiety disorder: A coordinate-based meta-analysis.Brain imaging and behavior · 2025Pooled it
- Effect of magnetic stimulation of Shenmen point on cognitive function of chronic insomnia: A randomized controlled clinical trial.Medicine · 2020Trial
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- Article
- Comparisons of resting-state brain activity between insomnia and schizophrenia: a coordinate-based meta-analysis.Schizophrenia (Heidelberg, Germany) · 2022Review
- Article
- Dynamic changes in fractional amplitude of low-frequency fluctuations in patients with chronic insomnia.Frontiers in neuroscience · 2022Article
- Functional Connectivity Density in the Sensorimotor Area is Associated with Sleep Latency in Patients with Primary Insomnia.Neuropsychiatric disease and treatment · 2022Article
- Distinct alterations of functional connectivity of the basal forebrain subregions in insomnia disorder.Frontiers in psychiatry · 2022Article
- Are Anti-Inflammatory Cytokines Associated with Cognitive Impairment in Patients with Insomnia Comorbid with Depression? A Pilot Study.Nature and science of sleep · 2021Article
- Interaction of Gut Microbiota and Brain Function in Patients With Chronic Insomnia: A Regional Homogeneity Study.Frontiers in neuroscience · 2021Article
- Central Sensitization-Related Changes in Brain Function Activity in a Rat Endometriosis-Associated Pain Model.Journal of pain research · 2020Article
- Evaluation of the brain functional activities in rats various location-endometriosis pain model.Annals of translational medicine · 2019Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeMany studies have shown that insomnia is an independent factor in cognitive impairment, but the involved neurobiological mechanisms remain unclear. We used regional homogeneity to explore the specific neurobiologic indicators of chronic insomnia disorder with mild cognitive impairment. MATERIALS AND
methodsThirty-nine patients with insomnia were divided into a group with and without cognitive impairment; we also included a control group (
resultsSubjective insomnia scores were negatively correlated with cognitive impairment after controlling for age, sex, and educational effects. Regions with significant differences in regional homogeneity values in the 3 groups were concentrated in the right medial prefrontal cortex, the right superior frontal gyrus, and the left superior occipital gyrus. Meanwhile, subjective insomnia scores were negatively correlated with the strength of the decreased regional homogeneity in the right medial prefrontal cortex. The increased regional homogeneity value in the right superior frontal gyrus was positively correlated with the Montreal Cognitive Assessment score in patients.
conclusionsOur results indicate that decreased regional homogeneity values in the medial prefrontal cortex and increased regional homogeneity values in the cuneus may be important neurobiologic indicators of chronic insomnia disorder and accompanying cognitive impairment. Overall, our study described the regional homogeneity of the whole brain in chronic insomnia disorder with mild cognitive impairment and could be the basis for future studies.
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