ArticleCirculation. Arrhythmia and electrophysiology2018
Global ECG Measures and Cardiac Structure and Function: The ARIC Study (Atherosclerosis Risk in Communities).
Abstract readMulticenter Study
In one paragraph
Article in Circulation. Arrhythmia and electrophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
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Who cites it
20 citing papers in PubMed.
- Prevention of Heart Failure in Hypertension-Disentangling the Role of Evolving Left Ventricular Hypertrophy and Blood Pressure Lowering: The ALLHAT Study.Journal of the American Heart Association · 2019Trial
- Larger spatial ventricular gradient magnitude is associated with higher rates of response to cardiac resynchronization therapy.Heart rhythm O2 · 2025Article
- Electrical Heterogeneity in Hispanic Background Subpopulations: The HCHS/SOL.JACC. Advances · 2024Article
- Latent profiles of global electrical heterogeneity: the Hispanic Community Health Study/Study of Latinos.European heart journal. Digital health · 2024Article
- Limited Relationship Between Echocardiographic Measures and Electrocardiographic Markers of Left Ventricular Size in Healthy Children.Pediatric cardiology · 2024Article
- Interactive teaching of medical 3D cardiac anatomy: atrial anatomy enhanced by ECG and 3D visualization.Frontiers in medicine · 2024Article
- The spatial ventricular gradient is associated with adverse outcomes in acute pulmonary embolism.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2023Article
- The Spatial Ventricular Gradient Is an Independent Predictor of Anthracycline-Associated Cardiotoxicity.JACC. Advances · 2023Article
- Unique Cardiovascular Disease Risk Factors in Hispanic Individuals.Current cardiovascular risk reports · 2022Review
- Electrocardiogram machine learning for detection of cardiovascular disease in African Americans: the Jackson Heart Study.European heart journal. Digital health · 2021Article
- Article
- Global electrical heterogeneity associated with drug-induced torsades de pointes.Heart rhythm · 2021Article
- Determining the thresholds for abnormal left ventricular strains in healthy subjects by echocardiography: a meta-analysis.Cardiovascular diagnosis and therapy · 2020Article
- Frontal QRS-T angle and ventricular mechanics in congenital heart disease.Heart and vessels · 2020Article
- The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions.Nature communications · 2020Review
- Changes in global electrical heterogeneity associated with dofetilide, quinidine, ranolazine, and verapamil.Heart rhythm · 2020Article
- QRS-T Angle Predicts Cardiac Risk and Correlates With Global Longitudinal Strain in Prevalent Hemodialysis Patients.Frontiers in physiology · 2019Article
- Global Electrical Heterogeneity: Mechanisms and Clinical Significance.Computing in cardiology · 2018Article
- The Reproducibility of Global Electrical Heterogeneity ECG Measurements.Computing in cardiology · 2018Article
- Reproducibility of global electrical heterogeneity measurements on 12-lead ECG: The Multi-Ethnic Study of Atherosclerosis.Journal of electrocardiologyArticle
Corrections and comments
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Authors and funding
10 authors.
Tor Biering-SørensenFrom the Brigham and Women's Hospital (T.B.-S., A.M.S., S.D.S.) and Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center (J.W.W., A.E.B.), Harvard Medical School, Boston, MA; Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., J.T., L.G.T.); Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.); and Epidemiological Cardiology Research Center, Cardiology Section, Department of Medicine, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.).
Muammar KabirFrom the Brigham and Women's Hospital (T.B.-S., A.M.S., S.D.S.) and Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center (J.W.W., A.E.B.), Harvard Medical School, Boston, MA; Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., J.T., L.G.T.); Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.); and Epidemiological Cardiology Research Center, Cardiology Section, Department of Medicine, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.).
Jonathan W WaksFrom the Brigham and Women's Hospital (T.B.-S., A.M.S., S.D.S.) and Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center (J.W.W., A.E.B.), Harvard Medical School, Boston, MA; Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., J.T., L.G.T.); Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.); and Epidemiological Cardiology Research Center, Cardiology Section, Department of Medicine, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.).
Jason ThomasFrom the Brigham and Women's Hospital (T.B.-S., A.M.S., S.D.S.) and Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center (J.W.W., A.E.B.), Harvard Medical School, Boston, MA; Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., J.T., L.G.T.); Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.); and Epidemiological Cardiology Research Center, Cardiology Section, Department of Medicine, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.).
Wendy S PostFrom the Brigham and Women's Hospital (T.B.-S., A.M.S., S.D.S.) and Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center (J.W.W., A.E.B.), Harvard Medical School, Boston, MA; Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., J.T., L.G.T.); Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.); and Epidemiological Cardiology Research Center, Cardiology Section, Department of Medicine, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.).
Elsayed Z SolimanFrom the Brigham and Women's Hospital (T.B.-S., A.M.S., S.D.S.) and Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center (J.W.W., A.E.B.), Harvard Medical School, Boston, MA; Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., J.T., L.G.T.); Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.); and Epidemiological Cardiology Research Center, Cardiology Section, Department of Medicine, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.).
Alfred E BuxtonFrom the Brigham and Women's Hospital (T.B.-S., A.M.S., S.D.S.) and Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center (J.W.W., A.E.B.), Harvard Medical School, Boston, MA; Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., J.T., L.G.T.); Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.); and Epidemiological Cardiology Research Center, Cardiology Section, Department of Medicine, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.).
Amil M ShahFrom the Brigham and Women's Hospital (T.B.-S., A.M.S., S.D.S.) and Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center (J.W.W., A.E.B.), Harvard Medical School, Boston, MA; Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., J.T., L.G.T.); Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.); and Epidemiological Cardiology Research Center, Cardiology Section, Department of Medicine, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.).
Scott D SolomonFrom the Brigham and Women's Hospital (T.B.-S., A.M.S., S.D.S.) and Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center (J.W.W., A.E.B.), Harvard Medical School, Boston, MA; Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., J.T., L.G.T.); Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.); and Epidemiological Cardiology Research Center, Cardiology Section, Department of Medicine, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.).
Larisa G TereshchenkoFrom the Brigham and Women's Hospital (T.B.-S., A.M.S., S.D.S.) and Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center (J.W.W., A.E.B.), Harvard Medical School, Boston, MA; Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., J.T., L.G.T.); Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.); and Epidemiological Cardiology Research Center, Cardiology Section, Department of Medicine, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.). tereshch@ohsu.edu.
Funding
University of Washington Biomedical Informatics and Data Science Research Training ProgramT15LM007442 · NLM · UNIVERSITY OF WASHINGTON · PI JOHN H. GENNARI, Andrea L. Hartzler · 2002 to 2026
$19.6MNovel ECG Measures and Risk of Sudden Cardiac DeathR01HL118277 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TERESHCHENKO, LARISA GENNADIEVNA · 2013 to 2016
$1.5MNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS R01 HL118277NLM NIH HHS T15 LM007442
Abstract
backgroundElectric excitation initiates myocardial mechanical contraction and coordinates myocardial pumping. We hypothesized that ECG global electric heterogeneity (GEH) and its longitudinal changes are associated with cardiac structure and function. METHODS AND
resultsParticipants from the ARIC study (Atherosclerosis Risk in Communities) (N=5114; 58% female; 22% blacks) with resting 12-lead ECGs (visits 1-5) and echocardiographic assessment of left ventricular (LV) ejection fraction, LV global longitudinal strain, LV mass index, LV end-diastolic volume index, and LV end-systolic volume index at visit 5 were included. Longitudinal analysis included ARIC participants (N=14 609) with measured GEH at visits 1 to 4. GEH was quantified by spatial ventricular gradient, QRS-T angle, and sum absolute QRS-T integral. Cross-sectional and longitudinal regressions were adjusted for manifest and subclinical cardiovascular disease. Having 4 abnormal GEH parameters was associated with a 6.4% (95% confidence interval, 5.5-7.3) LV ejection fraction decline, a 24.2 g/m
conclusionsGEH is a marker of subclinical abnormalities in cardiac structure and function.
Indexed as
AgedAtherosclerosisCross-Sectional StudiesDisease ProgressionEchocardiographyElectrocardiographyFemaleFollow-Up StudiesHeart VentriclesHumansMaleMiddle AgedMyocardial ContractionProspective StudiesRisk AssessmentRisk Factorsatherosclerosisdilatationelectrocardiographyhypertrophy, left ventricularvectorcardiography
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