ArticleJournal of the American Academy of Child and Adolescent Psychiatry2018
Effect of Time-Dependent Selective Serotonin Reuptake Inhibitor Antidepressants During Pregnancy on Behavioral, Emotional, and Social Development in Preschool-Aged Children.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Long-Term Effects of Intrauterine Exposure to Antidepressants on Physical, Neurodevelopmental, and Psychiatric Outcomes: A Systematic Review.The Journal of clinical psychiatry · 2020Pooled it
- The impact of maternal prenatal and postnatal anxiety on children's emotional problems: a systematic review.European child & adolescent psychiatry · 2019Pooled it
- Pooled it
- Prenatal exposure to maternal depression and antidepressants and neurodevelopmental outcomes: A population cohort study.PLoS medicine · 2026Article
- Impact of prenatal antidepressant exposure on trajectories of childhood emotions and behaviors: evidence from a birth cohort.Pediatric research · 2026Article
- Association of prenatal antidepressant use with internalizing behaviors from kindergarten to adolescence.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Prenatal depression and child developmental vulnerability.Pediatric research · 2025Article
- Citalopram exposure of hESCs during neuronal differentiation identifies dysregulated genes involved in neurodevelopment and depression.Frontiers in cell and developmental biology · 2024Article
- Article
- Long-Term Maternal and Child Outcomes Following Postnatal SSRI Treatment.JAMA network open · 2023Article
- Maternal SSRI use during pregnancy and offspring depression or anxiety disorders: A review of the literature and description of a study protocol for a register-based cohort study.Reproductive toxicology (Elmsford, N.Y.) · 2023Review
- Prenatal Selective Serotonin Reuptake Inhibitor Exposure, Depression, and Brain Morphology in Middle Childhood: Results From the ABCD Study.Biological psychiatry global open science · 2023Article
- Psychiatric visits during the postpartum year in women with eating disorders who continue or discontinue antidepressant treatment in pregnancy.The International journal of eating disorders · 2023Article
- Article
- Association of Antidepressant Use During Pregnancy With Risk of Neurodevelopmental Disorders in Children.JAMA internal medicine · 2022Article
- Perinatal exposure to fluoxetine and maternal adversity affect myelin-related gene expression and epigenetic regulation in the corticolimbic circuit of juvenile rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Longitudinal Methods for Modeling Exposures in Pharmacoepidemiologic Studies in Pregnancy.Epidemiologic reviews · 2022Review
- Interactions between maternal fluoxetine exposure, the maternal gut microbiome and fetal neurodevelopment in mice.Behavioural brain research · 2021Article
- Hypertensive disorders in pregnancy and child development at 36 months in the All Our Families prospective cohort study.PloS one · 2021Article
- Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Meta-Analysis of Pharmacotherapy.Psychiatric research and clinical practice · 2021Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate the effect of prenatal exposure to selective serotonin reuptake inhibitors (SSRIs) on children's behavioral, emotional, and social development by age 5 years, and over time since age 1.5 years.
methodThe prospective Norwegian Mother and Child Cohort Study was linked to the Medical Birth Registry of Norway. We included women who reported depressive/anxiety disorders before and/or during pregnancy. Children born to women who used SSRIs in early (weeks 0-16), mid- (weeks 17-28), or late (> week 29) pregnancy were compared to those who were unexposed. Children's internalizing and externalizing behaviors (Child Behavior Checklist) and temperament traits (Emotionality, Activity and Shyness Temperament Questionnaire) were measured at 1.5, 3, and 5 years. Mean scores were calculated and standardized. General linear marginal structural models were fitted to account for time-varying exposure and confounders, and censoring; 3-level growth-curve models were used.
resultsA total of 8,359 mother-child dyads were included, and 4,128 children had complete outcome data at age 5 years. Children exposed to SSRIs in late pregnancy had an increased risk of anxious/depressed behaviors by age 5 years compared with unexposed children (adjusted β = 0.50, 95% CI = 0.04, 0.96). Such risk was not evident for earlier timings of exposure. There was no evidence for a substantial prenatal SSRI effect on externalizing, social, and emotional problems.
conclusionThese findings suggest no substantial increased risk for externalizing, emotional, or social problems in preschool-aged children following prenatal SSRI exposure. Although the role of chance and potential unmeasured confounding cannot be ruled out, late-pregnancy SSRI exposure was associated with greater anxious/depressed behaviors in the offspring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.