ArticleJournal of the American Academy of Child and Adolescent Psychiatry2018
Identifying Clinically Significant Irritability in Early Childhood.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 3 of them syntheses that pooled it.
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Who cites it
66 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A Developmentally Informed Systematic Review and Meta-Analysis of the Strength of General Psychopathology in Childhood and Adolescence.Clinical child and family psychology review · 2024Pooled it
- Systematic Review and Meta-Analysis: Early Irritability as a Transdiagnostic Neurodevelopmental Vulnerability to Later Mental Health Problems.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Pooled it
- Diagnostic instruments for the assessment of disruptive mood dysregulation disorder: a systematic review of the literature.European child & adolescent psychiatry · 2023Pooled it
- Dysregulated Irritability as a Window on Young Children's Psychiatric Risk: Transdiagnostic Effects via the Family Check-Up.Development and psychopathology · 2019Trial
- Article
- Frustrative non-reward: A cross-species probe to study brain mechanisms of irritability.Translational psychiatry · 2026Review
- Associations of Tonic and Phasic Irritability With Psychopathology Subfactors of the Hierarchical Taxonomy of Psychopathology.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Disruptive behavior in preschoolers: associations with attention deficit hyperactivity disorder and parental psychopathology.BMC psychiatry · 2026Article
- SHAP-based explainable machine learning analysis of reward-related neural connectivity to predict preadolescent irritability.Neuroimage. Reports · 2026Article
- Cross-Cultural Consortium on Irritability (C3I): An International Network for Research on Cultural Similarities and Differences in Irritability.JAACAP open · 2026Article
- Measuring irritability across childhood, adolescence, and young adulthood: an investigation of measurement invariance by age, sex, and informant.European child & adolescent psychiatry · 2026Article
- Understanding temper loss in young children: Interactions among family violence, respiratory sinus arrhythmia, and frontal asymmetry.Psychoneuroendocrinology · 2025Article
- Article
- Developmental shifts in irritable behaviors from preschool to school age: Longitudinal network analysis of heterotypic and homotypic continuity.International journal of behavioral development · 2025Article
- The hidden burden: self-reported irritability in adolescent girls signals higher psychiatric risk.BMC public health · 2025Article
- Article
- How EASI can it be? Closing the research-to-practice gap via population-based validation of the MAPS-EASI 2.0 early childhood irritability screener for translation to clinical use.Translational issues in psychological science · 2024Article
- Early Predictors and Concurrent Correlates of Tonic and Phasic Irritability in Adolescence.Research on child and adolescent psychopathology · 2024Article
- A network approach to the investigation of childhood irritability: probing frustration using social stimuli.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Irritability in Youths: A Critical Integrative Review.The American journal of psychiatry · 2024Review
6 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
objectiveAdvances in developmentally sensitive measurement have enabled differentiation of normative versus clinically salient irritability in early childhood. However, clinical application of these measures is still nascent. The authors developed an optimized model of clinically salient irritable behaviors at preschool age. Based on this model, the authors derived an empirically based cutoff in relation to concurrent DSM-5 irritability-related disorders (i.e., oppositional defiant disorder, disruptive mood dysregulation disorder, other depressive disorders) and used longitudinal models to test the predictive validity of the cutoff for impairment and irritability trajectories and later DSM disorders.
methodPreschool children oversampled for irritability were followed over 3 time points into early school age (N = 425; mean age at baseline 4.7 years, mean follow-up 2.9 years). Mothers reported on children's irritability using the developmentally validated Multidimensional Assessment of Profile of Disruptive Behavior (MAP-DB) Temper Loss scale, impairment using the Family Life Impairment Scale, and DSM categories using the Preschool Age Psychiatric Assessment and the Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version.
resultsOf 22 MAP-DB Temper Loss behaviors, 2 behaviors-1 normative (easily frustrated) and 1 rare dysregulated (destructive tantrums)-were uniquely related to cross-domain impairment. At baseline, these 2 irritability items identified diagnostic status (oppositional defiant disorder, disruptive mood dysregulation disorder, other depressive disorders) with good sensitivity (70-73%) and specificity (74-83%). Children above the irritability cutoff at baseline also exhibited more persistent irritability and impairment and greater likelihood of DSM disorders in early school age.
conclusionClinical identification of early-onset irritability can be enhanced using brief, developmentally optimized indicators. Further research to apply these findings to tiered early intervention is important.
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