ArticleJournal of the American Academy of Child and Adolescent Psychiatry2018
Early Childhood Adverse Experiences, Inferior Frontal Gyrus Connectivity, and the Trajectory of Externalizing Psychopathology.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prenatal stress and externalizing behaviors in childhood and adolescence: A systematic review and meta-analysis.Psychological bulletin · 2024Pooled it
- Emotion Regulation Mediates the Link Between Exposure to Childhood Adversity and Transdiagnostic Symptom Domains in Youth.JAACAP open · 2026Article
- Altered dynamic functional connectivity of orbitofrontal cortex underlies olfactory and cognitive impairment in late-life depression.Psychoradiology · 2026Article
- Instability in the environment and children's in-school self-regulatory behaviors.Frontiers in psychology · 2025Article
- Associations between parental psychopathology and youth functional emotion regulation brain networks.Developmental cognitive neuroscience · 2024Article
- Article
- Disrupted functional connectivity of the habenula links psychomotor retardation and deficit of verbal fluency and working memory in late-life depression.CNS neuroscience & therapeutics · 2024Article
- A study on the association between prefrontal functional connectivity and non-suicidal self-injury in adolescents with depression.Frontiers in neurology · 2024Article
- Internalizing Symptoms and Adverse Childhood Experiences Associated With Functional Connectivity in a Middle Childhood Sample.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Self-Reported Gonadal Pubertal Timing Predicts Adolescent Borderline Personality Symptoms: Two Extended Replications With Prospective and Cross-Sectional Data.Journal of personality disorders · 2023Article
- Developmental pathways from preschool temper tantrums to later psychopathology.Development and psychopathology · 2023Article
- Neurobiological Clusters Are Associated With Trajectories of Overall Psychopathology in Youth.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Developmental trajectories of anger and sadness dysregulation in childhood differentially predict later borderline symptoms.Development and psychopathology · 2023Article
- Childhood poverty and mental health disorders in early adulthood: evidence from a Brazilian cohort study.European child & adolescent psychiatry · 2023Article
- Associations with youth psychotic-like experiences over time: Evidence for trans-symptom and specific cognitive and neural risk factors.Journal of psychopathology and clinical science · 2023Article
- The effects of sexual abuse on female adolescent brain structures.Scandinavian journal of child and adolescent psychiatry and psychology · 2023Article
- The influence of childhood emotional neglect experience on brain dynamic functional connectivity in young adults.European journal of psychotraumatology · 2023Article
- Impact of COVID-19 Related Maternal Stress on Fetal Brain Development: A Multimodal MRI Study.Journal of clinical medicine · 2022Article
- Impact of COVID-19 related maternal stress on fetal brain development: A Multimodal MRI study.medRxiv : the preprint server for health sciences · 2022Article
- Identifying moderating factors during the preschool period in the development of borderline personality disorder: a prospective longitudinal analysis.Borderline personality disorder and emotion dysregulation · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveEarly adverse childhood experiences (ACEs) have been linked to the development of both internalizing and externalizing psychopathology. In our prior work, we found that ACEs predicted reductions in the volume of the inferior frontal gyrus (IFG), a brain region important for impulse control and emotion regulation. Here we tested the hypothesis that ACEs might influence child behavioral outcomes through an impact on IFG functional connectivity, which may influence impulsive or risk-taking behavior.
methodWe examined the effects of prospectively assessed ACEs on IFG connectivity in childhood, and their relationship to the trajectory of subsequent psychopathology from late school age and early adolescence, using data from an 11-year longitudinal study of children starting in preschool that included 3 waves of resting state functional connectivity across childhood and early adolescence.
resultsACEs predicted functional connectivity of both left and right IFG. Multi-level modeling of symptoms across 3 waves of assessments indicated that more ACEs predicted both internalizing and externalizing symptoms. However, altered IFG connectivity specifically predicted greater externalizing symptoms over time in middle childhood and early adolescence, as compared to internalizing symptoms. Longitudinal modeling indicating that the relationships between externalizing and functional connectivity were maintained across 3 waves of functional connectivity assessment.
conclusionThese findings underscore the relationship of ACEs to later psychopathology, and suggest that connectivity of the IFG, a region known to play an important role in impulse control and emotion regulation, may play a key role in the risk trajectory of ACEs to externalizing problems. However, further work is needed to understand whether these relationships reflect a direct effect of ACEs or whether ACEs are a marker for other environmental or genetic factors that may also influence brain development and behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.