ArticleOral oncology2018
Characterization of epithelial oral dysplasia in non-smokers: First steps towards precision medicine.
Article in Oral oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Clinical Features Associated With Malignant Transformation of Low-Grade Dysplasia.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026Article
- Robust HPV-16 Detection Workflow for Formalin-Fixed Cancer Tissue and Its Application for Oral Squamous Cell Carcinoma.Cancer medicine · 2025Article
- A fully automated and explainable algorithm for predicting malignant transformation in oral epithelial dysplasia.NPJ precision oncology · 2024Article
- Oral Epithelial Dysplasia in Tobacco Non-habitués: A Case Report and Review of Literature.Cureus · 2023Article
- Effect of educational intervention based on theory of planned behaviour on promoting preventive behaviours of oral cancer in rural women.BMC women's health · 2023Article
- Exploring the microbiome of oral epithelial dysplasia as a predictor of malignant progression.BMC oral health · 2023Article
- Influence of site and smoking on malignant transformation in the oral cavity: Is the microbiome the missing link?Frontiers in oral health · 2023Review
- Molecular drivers of oral cavity squamous cell carcinoma in non-smoking and non-drinking patients: what do we know so far?Oncology reviews · 2022Article
- Review
- Malignant transformation of oral leukoplakia: a multicentric retrospective study in Brazilian population.Medicina oral, patologia oral y cirugia bucal · 2021Article
- Difficulties in the Prognostic Study of Oral Leukoplakia: Standardisation Proposal of Follow-Up Parameters.Frontiers in oral health · 2021Review
- UK consensus recommendations on the management of oral epithelial dysplasia during COVID-19 pandemic outbreaks.Oral oncology · 2021Article
- Article
- New Insights into Oral Cancer-Risk Factors and Prevention: A Review of Literature.International journal of preventive medicine · 2020Review
- Autofluorescence Imaging to Monitor the Progression of Oral Potentially Malignant Disorders.Cancer prevention research (Philadelphia, Pa.) · 2019Article
- Expanding the Transcriptome of Head and Neck Squamous Cell Carcinoma Through Novel MicroRNA Discovery.Frontiers in oncology · 2019Article
- Loss of heterozygosity as a marker to predict progression of oral epithelial dysplasia to oral squamous cell carcinoma.Journal of oral and maxillofacial pathology : JOMFPArticle
- Atypical extragingival occurrence of lobular capillary hemangioma: A report of two cases.Journal of Indian Society of PeriodontologyArticle
- Simulation Modeling of Oral Cancer Development with Risk Stratification: How Potential Screening Programs Can Be Evaluated.MDM policy & practiceArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesTobacco usage is the strongest risk factor in the development of oral squamous cell carcinoma (OSCC), which mandates careful screening for oral cancers in smokers. However, there are indications that oral potentially malignant lesions, such as oral epithelial dysplasia (OED), in non-smokers (NS) have a higher cancer risk than those in smokers. Without tobacco as an etiology, the development of these lesions in NS may suggest genetic susceptibility. The increasing incidence of OSCC in NS calls for a better understanding of the natural history of OED in NS as compared to that of smokers. MATERIALS AND
methodsPatients from a population-based longitudinal study with more than 10 years of follow up were analyzed. Of the 455 patients with primary OED (233 mild and 212 moderate dysplasia), 139 were NS and 306 were smokers. Demographic and habit information, clinical information (lesion site, size and appearance; toluidine blue and fluorescent visualization), microsatellite analysis for loss of heterozygosity (LOH) and outcome (progression) were compared between the two groups. RESULTS AND
conclusionsThe majority of patients with OED were smokers. Of these, more were males, non-Caucasians and heavy drinkers. A significantly higher number of OED in NS were in the tongue, whereas a significantly higher number of OED in smokers were in the floor of mouth (FOM). OED in NS showed a greater than 2-fold increase in cancer progression. Strikingly, OED located in the FOM in NS showed a 38-fold increase in cancer progression as compared to those in smokers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.