ArticleJournal of the American College of Cardiology2018
Gadolinium-Free Cardiac MR Stress T1-Mapping to Distinguish Epicardial From Microvascular Coronary Disease.
Article in Journal of the American College of Cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Evaluation of non-invasive imaging parameters in coronary microvascular disease: a systematic review.BMC medical imaging · 2021Pooled it
- Accelerated cardiac T1 mapping with recurrent networks and cyclic, model-based loss.Medical physics · 2022Article
- Definition and epidemiology of coronary microvascular disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Review
- Article
- Native T1 mapping and extracellular volume fraction for differentiation of myocardial diseases from normal CMR controls in routine clinical practice.BMC cardiovascular disorders · 2021Article
- Microvascular Dysfunction in Diabetes Mellitus and Cardiometabolic Disease.Endocrine reviews · 2021Review
- Research Progress of Imaging Methods for Detection of Microvascular Angina Pectoris in Diabetic Patients.Frontiers in cardiovascular medicine · 2021Review
- 3D-Printed Coronary Implants Are Effective for Percutaneous Creation of Swine Models with Focal Coronary Stenosis.Journal of cardiovascular translational research · 2020Article
- Pathophysiology, classification, and MRI parallels in microvascular disease of the heart and brain.Microcirculation (New York, N.Y. : 1994) · 2020Review
- [Advancement of imaging technology for coronary microcirculation dysfunction assessment].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Review
- Left ventricular ischemia in pre-capillary pulmonary hypertension: a cardiovascular magnetic resonance study.Cardiovascular diagnosis and therapy · 2020Article
- Coronary Microvascular Dysfunction and the Role of Noninvasive Cardiovascular Imaging.Diagnostics (Basel, Switzerland) · 2020Review
- Clinical assessment of adenosine stress and rest cardiac magnetic resonance T1 mapping for detecting ischemic and infarcted myocardium.Scientific reports · 2020Article
- Coronary Microvascular Dysfunction.Journal of clinical medicine · 2020Review
- Ischaemia with no obstructive coronary arteries.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2020Review
- Clinical quantitative cardiac imaging for the assessment of myocardial ischaemia.Nature reviews. Cardiology · 2020Article
- Real-time cardiovascular magnetic resonance T1 and extracellular volume fraction mapping for tissue characterisation in aortic stenosis.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Article
- The reliability and feasibility of non-contrast adenosine stress cardiovascular magnetic resonance T1 mapping in patients on haemodialysis.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Article
- (Epicardial and microvascular) angina or atypical chest pain: differential diagnoses with cardiovascular magnetic resonance.European heart journal supplements : journal of the European Society of Cardiology · 2020Article
- Microvascular Disease and Small-Vessel Disease: The Nexus of Multiple Diseases of Women.Journal of women's health (2002) · 2020Article
Corrections and comments
- Retraction · 2020-10-12Complaints about Company/Institution · Falsification/Fabrication of Data · Falsification/Fabrication of Image · Investigation by Company/Institution · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · Objections by Author(s) ·
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- Retracted
Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundNovel cardiac magnetic resonance (CMR) stress T1 mapping can detect ischemia and myocardial blood volume changes without contrast agents and may be a more comprehensive ischemia biomarker than myocardial blood flow.
objectivesThis study describes the performance of the first prospective validation of stress T1 mapping against invasive coronary measurements for detecting obstructive epicardial coronary artery disease (CAD), defined by fractional flow reserve (FFR <0.8), and coronary microvascular dysfunction, defined by FFR ≥0.8 and the index of microcirculatory resistance (IMR ≥25 U), compared with first-pass perfusion imaging.
methodsNinety subjects (60 patients with angina; 30 healthy control subjects) underwent CMR (1.5- and 3-T) to assess left ventricular function (cine), ischemia (adenosine stress/rest T1 mapping and perfusion), and infarction (late gadolinium enhancement). FFR and IMR were assessed ≤7 days post-CMR. Stress and rest images were analyzed blinded to other information.
resultsNormal myocardial T1 reactivity (ΔT1) was 6.2 ± 0.4% (1.5-T) and 6.2 ± 1.3% (3-T). Ischemic viable myocardium downstream of obstructive CAD showed near-abolished T1 reactivity (ΔT1 = 0.7 ± 0.7%). Myocardium downstream of nonobstructive coronary arteries with microvascular dysfunction showed less-blunted T1 reactivity (ΔT1 = 3.0 ± 0.9%). Stress T1 mapping significantly outperformed gadolinium-based first-pass perfusion, including absolute quantification of myocardial blood flow, for detecting obstructive CAD (area under the receiver-operating characteristic curve: 0.97 ± 0.02 vs. 0.91 ± 0.03, respectively; p < 0.001). A ΔT1 of 1.5% accurately detected obstructive CAD (sensitivity: 93%; specificity: 95%; p < 0.001), whereas a less-blunted ΔT1 of 4.0% accurately detected microvascular dysfunction (area under the receiver-operating characteristic curve: 0.95 ± 0.03; sensitivity: 94%; specificity: 94%: p < 0.001).
conclusionsCMR stress T1 mapping accurately detected and differentiated between obstructive epicardial CAD and microvascular dysfunction, without contrast agents or radiation.
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