Evidence map›Paper›PMID 29495939›Full record

ArticleInnate immunity2018

Disruption of transient receptor potential melastatin 2 decreases elastase release and bacterial clearance in neutrophils.

XiaoWei Qian, Hang Zhao, XinZhong Chen, Jun Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Innate immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Intricate Interplay between Innate Immune Cells and TRMP2 in a Mouse Model of Multiple Sclerosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  7. The function of TRP channels in neutrophil granulocytes.Pflugers Archiv : European journal of physiology · 2018
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

XiaoWei Qian1 Department of Anesthesiology, Women's Hospital, School of Medicine, Zhejiang University, China.
Hang Zhao3 Department of Anesthesiology, Yancheng Third People's Hospital, China.
XinZhong Chen1 Department of Anesthesiology, Women's Hospital, School of Medicine, Zhejiang University, China.
Jun Li2 Department of Anesthesiology, Critical Care and Pain Medicine, The Second Affiliated Hospital and Yuying Children Hospital of Wenzhou Medical University, China.
Women's Hospital, School of Medicine, Zhejiang University · CNWenzhou Medical University · CNYancheng Third People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elastase released by neutrophils is critical for eliminating Gram-negative bacteria. Ca

Indexed as

AnimalsBacterial LoadCalcium SignalingCells, CulturedEscherichia coliEscherichia coli InfectionsMaleMiceMice, Inbred C57BLMice, KnockoutNeutrophilsp38 Mitogen-Activated Protein KinasesPancreatic ElastasePhosphorylationTRPM Cation Channelsp38 Mitogen-Activated Protein KinasesPancreatic ElastaseTRPM2 protein, mouseTRPM Cation Channelsbacterial clearanceelastaseneutrophilssepsisTransient receptor potential melastatin 2

Identifiers

PMID29495939
PMCPMC6830898
OpenAlexW2792491914

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.