Evidence map›Paper›PMID 29495896›Full record

ArticleThe American journal of psychiatry2018

Polygenic Risk Score for Alzheimer's Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life.

Luiza K Axelrud, Marcos L Santoro, Daniel S Pine, Fernanda Talarico, Ary Gadelha, Gisele G Manfro, Pedro M Pan, Andrea Jackowski, Felipe Picon, Elisa Brietzke and 9 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.

  1. Pooled it
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  5. White Matter Microstructural Alterations Mediate the Association between Polygenic Risk for Alzheimer's Disease and Cognitive Performance in Clinically Asymptomatic Adults.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
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  20. Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Luiza K AxelrudFrom the Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Section on Negative Affect and Social Processes, Porto Alegre, Brazil; the National Institute of Developmental Psychiatry, São Paulo, Brazil; the Department of Morphology and Genetics and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; the Emotion and Development Branch, NIMH, Bethesda, Md.; the Graduate Program in Pediatric and Child Health, Pontificial Catholic University of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Porto Alegre, Brazil; the Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia; the Rotman Research Institute, Baycrest, Toronto; the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Child Mind Institute, New York; and the Hospital for Sick Children, University of Toronto, Toronto.
Marcos L SantoroFrom the Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Section on Negative Affect and Social Processes, Porto Alegre, Brazil; the National Institute of Developmental Psychiatry, São Paulo, Brazil; the Department of Morphology and Genetics and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; the Emotion and Development Branch, NIMH, Bethesda, Md.; the Graduate Program in Pediatric and Child Health, Pontificial Catholic University of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Porto Alegre, Brazil; the Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia; the Rotman Research Institute, Baycrest, Toronto; the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Child Mind Institute, New York; and the Hospital for Sick Children, University of Toronto, Toronto.
Daniel S PineFrom the Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Section on Negative Affect and Social Processes, Porto Alegre, Brazil; the National Institute of Developmental Psychiatry, São Paulo, Brazil; the Department of Morphology and Genetics and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; the Emotion and Development Branch, NIMH, Bethesda, Md.; the Graduate Program in Pediatric and Child Health, Pontificial Catholic University of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Porto Alegre, Brazil; the Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia; the Rotman Research Institute, Baycrest, Toronto; the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Child Mind Institute, New York; and the Hospital for Sick Children, University of Toronto, Toronto.
Fernanda TalaricoFrom the Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Section on Negative Affect and Social Processes, Porto Alegre, Brazil; the National Institute of Developmental Psychiatry, São Paulo, Brazil; the Department of Morphology and Genetics and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; the Emotion and Development Branch, NIMH, Bethesda, Md.; the Graduate Program in Pediatric and Child Health, Pontificial Catholic University of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Porto Alegre, Brazil; the Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia; the Rotman Research Institute, Baycrest, Toronto; the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Child Mind Institute, New York; and the Hospital for Sick Children, University of Toronto, Toronto.
Ary GadelhaFrom the Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Section on Negative Affect and Social Processes, Porto Alegre, Brazil; the National Institute of Developmental Psychiatry, São Paulo, Brazil; the Department of Morphology and Genetics and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; the Emotion and Development Branch, NIMH, Bethesda, Md.; the Graduate Program in Pediatric and Child Health, Pontificial Catholic University of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Porto Alegre, Brazil; the Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia; the Rotman Research Institute, Baycrest, Toronto; the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Child Mind Institute, New York; and the Hospital for Sick Children, University of Toronto, Toronto.
Gisele G ManfroFrom the Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Section on Negative Affect and Social Processes, Porto Alegre, Brazil; the National Institute of Developmental Psychiatry, São Paulo, Brazil; the Department of Morphology and Genetics and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; the Emotion and Development Branch, NIMH, Bethesda, Md.; the Graduate Program in Pediatric and Child Health, Pontificial Catholic University of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Porto Alegre, Brazil; the Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia; the Rotman Research Institute, Baycrest, Toronto; the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Child Mind Institute, New York; and the Hospital for Sick Children, University of Toronto, Toronto.
Pedro M PanFrom the Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Section on Negative Affect and Social Processes, Porto Alegre, Brazil; the National Institute of Developmental Psychiatry, São Paulo, Brazil; the Department of Morphology and Genetics and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; the Emotion and Development Branch, NIMH, Bethesda, Md.; the Graduate Program in Pediatric and Child Health, Pontificial Catholic University of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Porto Alegre, Brazil; the Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia; the Rotman Research Institute, Baycrest, Toronto; the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Child Mind Institute, New York; and the Hospital for Sick Children, University of Toronto, Toronto.
Andrea JackowskiFrom the Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Section on Negative Affect and Social Processes, Porto Alegre, Brazil; the National Institute of Developmental Psychiatry, São Paulo, Brazil; the Department of Morphology and Genetics and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; the Emotion and Development Branch, NIMH, Bethesda, Md.; the Graduate Program in Pediatric and Child Health, Pontificial Catholic University of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Porto Alegre, Brazil; the Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia; the Rotman Research Institute, Baycrest, Toronto; the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Child Mind Institute, New York; and the Hospital for Sick Children, University of Toronto, Toronto.
Felipe PiconFrom the Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Section on Negative Affect and Social Processes, Porto Alegre, Brazil; the National Institute of Developmental Psychiatry, São Paulo, Brazil; the Department of Morphology and Genetics and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; the Emotion and Development Branch, NIMH, Bethesda, Md.; the Graduate Program in Pediatric and Child Health, Pontificial Catholic University of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Porto Alegre, Brazil; the Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia; the Rotman Research Institute, Baycrest, Toronto; the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Child Mind Institute, New York; and the Hospital for Sick Children, University of Toronto, Toronto.
Elisa BrietzkeFrom the Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Section on Negative Affect and Social Processes, Porto Alegre, Brazil; the National Institute of Developmental Psychiatry, São Paulo, Brazil; the Department of Morphology and Genetics and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; the Emotion and Development Branch, NIMH, Bethesda, Md.; the Graduate Program in Pediatric and Child Health, Pontificial Catholic University of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Porto Alegre, Brazil; the Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia; the Rotman Research Institute, Baycrest, Toronto; the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Child Mind Institute, New York; and the Hospital for Sick Children, University of Toronto, Toronto.
Rodrigo Grassi-OliveiraFrom the Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Section on Negative Affect and Social Processes, Porto Alegre, Brazil; the National Institute of Developmental Psychiatry, São Paulo, Brazil; the Department of Morphology and Genetics and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; the Emotion and Development Branch, NIMH, Bethesda, Md.; the Graduate Program in Pediatric and Child Health, Pontificial Catholic University of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Porto Alegre, Brazil; the Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia; the Rotman Research Institute, Baycrest, Toronto; the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Child Mind Institute, New York; and the Hospital for Sick Children, University of Toronto, Toronto.
Rodrigo A BressanFrom the Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Section on Negative Affect and Social Processes, Porto Alegre, Brazil; the National Institute of Developmental Psychiatry, São Paulo, Brazil; the Department of Morphology and Genetics and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; the Emotion and Development Branch, NIMH, Bethesda, Md.; the Graduate Program in Pediatric and Child Health, Pontificial Catholic University of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Porto Alegre, Brazil; the Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia; the Rotman Research Institute, Baycrest, Toronto; the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Child Mind Institute, New York; and the Hospital for Sick Children, University of Toronto, Toronto.
Eurípedes C MiguelFrom the Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Section on Negative Affect and Social Processes, Porto Alegre, Brazil; the National Institute of Developmental Psychiatry, São Paulo, Brazil; the Department of Morphology and Genetics and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; the Emotion and Development Branch, NIMH, Bethesda, Md.; the Graduate Program in Pediatric and Child Health, Pontificial Catholic University of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Porto Alegre, Brazil; the Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia; the Rotman Research Institute, Baycrest, Toronto; the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Child Mind Institute, New York; and the Hospital for Sick Children, University of Toronto, Toronto.
Luis A RohdeFrom the Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Section on Negative Affect and Social Processes, Porto Alegre, Brazil; the National Institute of Developmental Psychiatry, São Paulo, Brazil; the Department of Morphology and Genetics and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; the Emotion and Development Branch, NIMH, Bethesda, Md.; the Graduate Program in Pediatric and Child Health, Pontificial Catholic University of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Porto Alegre, Brazil; the Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia; the Rotman Research Institute, Baycrest, Toronto; the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Child Mind Institute, New York; and the Hospital for Sick Children, University of Toronto, Toronto.
Hakon HakonarsonFrom the Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Section on Negative Affect and Social Processes, Porto Alegre, Brazil; the National Institute of Developmental Psychiatry, São Paulo, Brazil; the Department of Morphology and Genetics and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; the Emotion and Development Branch, NIMH, Bethesda, Md.; the Graduate Program in Pediatric and Child Health, Pontificial Catholic University of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Porto Alegre, Brazil; the Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia; the Rotman Research Institute, Baycrest, Toronto; the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Child Mind Institute, New York; and the Hospital for Sick Children, University of Toronto, Toronto.
Zdenka PausovaFrom the Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Section on Negative Affect and Social Processes, Porto Alegre, Brazil; the National Institute of Developmental Psychiatry, São Paulo, Brazil; the Department of Morphology and Genetics and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; the Emotion and Development Branch, NIMH, Bethesda, Md.; the Graduate Program in Pediatric and Child Health, Pontificial Catholic University of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Porto Alegre, Brazil; the Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia; the Rotman Research Institute, Baycrest, Toronto; the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Child Mind Institute, New York; and the Hospital for Sick Children, University of Toronto, Toronto.
Sintia BelangeroFrom the Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Section on Negative Affect and Social Processes, Porto Alegre, Brazil; the National Institute of Developmental Psychiatry, São Paulo, Brazil; the Department of Morphology and Genetics and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; the Emotion and Development Branch, NIMH, Bethesda, Md.; the Graduate Program in Pediatric and Child Health, Pontificial Catholic University of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Porto Alegre, Brazil; the Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia; the Rotman Research Institute, Baycrest, Toronto; the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Child Mind Institute, New York; and the Hospital for Sick Children, University of Toronto, Toronto.
Tomas PausFrom the Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Section on Negative Affect and Social Processes, Porto Alegre, Brazil; the National Institute of Developmental Psychiatry, São Paulo, Brazil; the Department of Morphology and Genetics and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; the Emotion and Development Branch, NIMH, Bethesda, Md.; the Graduate Program in Pediatric and Child Health, Pontificial Catholic University of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Porto Alegre, Brazil; the Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia; the Rotman Research Institute, Baycrest, Toronto; the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Child Mind Institute, New York; and the Hospital for Sick Children, University of Toronto, Toronto.
Giovanni A SalumFrom the Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Section on Negative Affect and Social Processes, Porto Alegre, Brazil; the National Institute of Developmental Psychiatry, São Paulo, Brazil; the Department of Morphology and Genetics and the Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; the Emotion and Development Branch, NIMH, Bethesda, Md.; the Graduate Program in Pediatric and Child Health, Pontificial Catholic University of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Porto Alegre, Brazil; the Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil; the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia; the Rotman Research Institute, Baycrest, Toronto; the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Child Mind Institute, New York; and the Hospital for Sick Children, University of Toronto, Toronto.
Universidade Federal do Rio Grande do Sul · BR

Funding

fMRI Studies Of Pediatric Mood And Anxiety DisordersZIAMH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$41.5M
CIHRIntramural NIH HHS Z99 MH999999
6 · The paper itself

Abstract

objectiveAlzheimer's disease is a heritable neurodegenerative disorder in which early-life precursors may manifest in cognition and brain structure. The authors evaluate this possibility by examining, in youths, associations among polygenic risk score for Alzheimer's disease, cognitive abilities, and hippocampal volume.

methodParticipants were children 6-14 years of age in two Brazilian cities, constituting the discovery (N=364) and replication samples (N=352). As an additional replication, data from a Canadian sample (N=1,029), with distinct tasks, MRI protocol, and genetic risk, were included. Cognitive tests quantified memory and executive function. Reading and writing abilities were assessed by standardized tests. Hippocampal volumes were derived from the Multiple Automatically Generated Templates (MAGeT) multi-atlas segmentation brain algorithm. Genetic risk for Alzheimer's disease was quantified using summary statistics from the International Genomics of Alzheimer's Project.

resultsAnalyses showed that for the Brazilian discovery sample, each one-unit increase in z-score for Alzheimer's polygenic risk score significantly predicted a 0.185 decrement in z-score for immediate recall and a 0.282 decrement for delayed recall. Findings were similar for the Brazilian replication sample (immediate and delayed recall, β=-0.259 and β=-0.232, both significant). Quantile regressions showed lower hippocampal volumes bilaterally for individuals with high polygenic risk scores. Associations fell short of significance for the Canadian sample.

conclusionsGenetic risk for Alzheimer's disease may affect early-life cognition and hippocampal volumes, as shown in two independent samples. These data support previous evidence that some forms of late-life dementia may represent developmental conditions with roots in childhood. This result may vary depending on a sample's genetic risk and may be specific to some types of memory tasks.

Indexed as

AdolescentAlzheimer DiseaseBrazilCanadaChildCognitionFemaleHippocampusHumansMaleMemoryMultifactorial InheritanceNeuropsychological TestsOrgan SizeRisk FactorsAlzheimer’s diseaseHippocampusMemoryPolygenic risk score

Identifiers

PMID29495896
PMCPMC6372950
OpenAlexW2793509733

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.