Evidence map›Paper›PMID 29495523›Full record

ArticleJournal of functional biomaterials2018

Electron Beam Immobilization of Novel Antimicrobial, Short Peptide Motifs Leads to Membrane Surfaces with Promising Antibacterial Properties.

André Reinhardt, Isabell Thomas, Julie Schmauck, Ralf Giernoth, Agnes Schulze, Ines Neundorf

Abstract read
In one paragraph

Article in Journal of functional biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

André ReinhardtDepartment of Chemistry, Biochemistry, University of Cologne, Zülpicher Str. 47a, D-50674 Cologne, Germany. andre.reinhardt1@gmx.de.
Isabell ThomasLeibniz Institute of Surface Engineering, Permoserstr. 15, D-04318 Leipzig, Germany. isabell.thomas@iom-leipzig.de.
Julie SchmauckDepartment of Chemistry, Organic Chemistry, University of Cologne, Greinstr. 4, D-50939 Cologne, Germany. jpieperg@smail.uni-koeln.de.
Ralf GiernothDepartment of Chemistry, Organic Chemistry, University of Cologne, Greinstr. 4, D-50939 Cologne, Germany. ralf.giernoth@uni-koeln.de.ORCID 0000-0003-2282-6586
Agnes SchulzeLeibniz Institute of Surface Engineering, Permoserstr. 15, D-04318 Leipzig, Germany. agnes.schulze@iom-leipzig.de.ORCID 0000-0003-1316-1367
Ines NeundorfDepartment of Chemistry, Biochemistry, University of Cologne, Zülpicher Str. 47a, D-50674 Cologne, Germany. ines.neundorf@uni-koeln.de.ORCID 0000-0001-6450-3991

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, the efficacy of electron beam irradiation versus chemical coupling for yielding polyethersulfone (PES) membranes with antibacterial properties was investigated. For the surface coating, a recently discovered lead compound, IL-KKA, comprising a short peptide sequence functionalized with imidazolium groups, was used. For better integration within the membrane, several novel variants of IL-KKA were generated. Membrane immobilization was achieved using different doses of electron beam irradiation and NHS/EDC chemical coupling. Physicochemical characterization of the coated membranes was performed by water contact angle measurements, X-ray photoelectron spectroscopy, and scanning electron microscopy. Our results show that electron beam irradiation is as effective and gentle as chemical coupling using the NHS/EDC method. Moreover, it was demonstrated that the obtained membranes exhibit promising antibacterial activity against

Indexed as

antimicrobial peptidesbiofilm formationelectron beamimmobilization techniquessurface modification

Identifiers

PMID29495523
PMCPMC5872107

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.