Evidence map›Paper›PMID 29495467›Full record

ArticleNutrients2018

MS Sunshine Study: Sun Exposure But Not Vitamin D Is Associated with Multiple Sclerosis Risk in Blacks and Hispanics.

Annette Langer-Gould, Robyn Lucas, Anny H Xiang, Lie H Chen, Jun Wu, Edlin Gonzalez, Samantha Haraszti, Jessica B Smith, Hong Quach, Lisa F Barcellos

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Toward a global research agenda for preventing multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Seasonal variation in sunlight exposure is differently associated with changes in T regulatory and T-helper 17 cell blood counts in adolescent and adults females: a pilot study.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Article
  10. Article
  11. Multiple Sclerosis, Rituximab, Hypogammaglobulinemia, and Risk of Infections.Neurology(R) neuroimmunology & neuroinflammation · 2024
    Article
  12. Multiple Sclerosis, Disease-Modifying Therapies, and Infections.Neurology(R) neuroimmunology & neuroinflammation · 2023
    Article
  13. Article
  14. The effects of exposure to solar radiation on human health.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023
    Article
  15. High-dose vitamin DEClinicalMedicine · 2023
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Annette Langer-GouldLos Angeles Medical Center, Department of Neurology, Southern California Permanente Medical Group, 100 S Los Robles, Pasadena, CA 91101, USA. Annette.M.Langer-Gould@kp.org.
Robyn LucasCollege of Medicine, Biology & Environment, Australian National University, Canberra, ACT 2000, Australia. robyn.lucas@anu.edu.au.ORCID 0000-0003-2736-3541
Anny H XiangDepartment of Research & Evaluation, Kaiser Permanente Southern California, 100 S. Los Robles Avenue, Pasadena, CA 91101, USA. anny.h.xiang@kp.org.
Lie H ChenDepartment of Research & Evaluation, Kaiser Permanente Southern California, 100 S. Los Robles Avenue, Pasadena, CA 91101, USA. lie.h.chen@kp.org.
Jun WuDepartment of Research & Evaluation, Kaiser Permanente Southern California, 100 S. Los Robles Avenue, Pasadena, CA 91101, USA. jun.x.wu@kp.org.
Edlin GonzalezDepartment of Research & Evaluation, Kaiser Permanente Southern California, 100 S. Los Robles Avenue, Pasadena, CA 91101, USA. edlin.g.gonzales@kp.org.
Samantha HarasztiDepartment of Research & Evaluation, Kaiser Permanente Southern California, 100 S. Los Robles Avenue, Pasadena, CA 91101, USA. samanthaha@pcom.edu.
Jessica B SmithDepartment of Research & Evaluation, Kaiser Permanente Southern California, 100 S. Los Robles Avenue, Pasadena, CA 91101, USA. Jessica.b.smith@kp.org.
Hong QuachQB3 Genetic Epidemiology and Genomics Lab, School of Public Health, University of California Berkeley, 209 Hildebrand Hall, Berkeley, CA 94720-7356, USA. hquach@berkeley.edu.
Lisa F BarcellosQB3 Genetic Epidemiology and Genomics Lab, School of Public Health, University of California Berkeley, 209 Hildebrand Hall, Berkeley, CA 94720-7356, USA. lbarcellos@berkeley.edu.
Kaiser Permanente · USUniversity of California, Berkeley · USAustralian National University · AULos Angeles Medical Center · USPhiladelphia College of Osteopathic Medicine · US

Funding

Vitamin D, Race/Ethnicity, Genotype, and Multiple SclerosisR01NS075308 · NINDS · KAISER FOUNDATION RESEARCH INSTITUTE · PI LANGER-GOULD, ANNETTE M · 2011 to 2015
$3.0M
NINDS NIH HHS R01 NS075308
6 · The paper itself

Abstract

Multiple sclerosis (MS) incidence and serum 25-hydroxyvitamin D (25OHD) levels vary by race/ethnicity. We examined the consistency of beneficial effects of 25OHD and/or sun exposure for MS risk across multiple racial/ethnic groups. We recruited incident MS cases and controls (blacks 116 cases/131 controls; Hispanics 183/197; whites 247/267) from the membership of Kaiser Permanente Southern California into the MS Sunshine Study to simultaneously examine sun exposure and 25OHD, accounting for genetic ancestry and other factors. Higher lifetime ultraviolet radiation exposure (a rigorous measure of sun exposure) was associated with a lower risk of MS independent of serum 25OHD levels in blacks (adjusted OR = 0.53, 95% CI = 0.31-0.83;

Indexed as

Black PeopleHispanic or LatinoSunlightAdultAllelesBlack or African AmericanBody Mass IndexCaliforniaCase-Control StudiesDietary SupplementsFemaleGenotyping TechniquesHistocompatibility Antigens Class IIHumansIncidenceMaleHistocompatibility Antigens Class IIVitamin DblacksHispanicsmultiple sclerosissun exposurevitamin D

Identifiers

PMID29495467
PMCPMC5872686
OpenAlexW2790990940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.